dc.contributor.author | Georgiades, Savvas N. | en |
dc.contributor.author | Abd Karim, N. H. | en |
dc.contributor.author | Suntharalingam, K. | en |
dc.contributor.author | Vilar, R. | en |
dc.creator | Georgiades, Savvas N. | en |
dc.creator | Abd Karim, N. H. | en |
dc.creator | Suntharalingam, K. | en |
dc.creator | Vilar, R. | en |
dc.date.accessioned | 2019-11-21T06:19:05Z | |
dc.date.available | 2019-11-21T06:19:05Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55491 | |
dc.description.abstract | [Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several key biological processes. In the human genome, guanine-rich sequences with the potential to form G-quadruplexes exist in the telomere as well as in promoter regions of certain oncogenes. The identification of these sequences as novel targets for the development of anticancer drugs has sparked great interest in the design of molecules that can interact with quadruplex DNA. While most reported quadruplex DNA binders are based on purely organic templates, numerous metal complexes have more recently been shown to interact effectively with this DNA secondary structure. This Review provides an overview of the important roles that metal complexes can play as quadruplex DNA binding molecules, highlighting the unique properties metals can confer to these molecules. © 2010 Wiley-VCH Verlag GmbH & Co. KCaA,. | en |
dc.source | Angewandte Chemie - International Edition | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953111689&doi=10.1002%2fanie.200906363&partnerID=40&md5=c81ea7ac0a2ac16ab733e83d1a3532dd | |
dc.subject | antineoplastic agent | en |
dc.subject | Antineoplastic Agents | en |
dc.subject | review | en |
dc.subject | Genes | en |
dc.subject | DNA | en |
dc.subject | chemistry | en |
dc.subject | Positive ions | en |
dc.subject | Metals | en |
dc.subject | Molecules | en |
dc.subject | Complexation | en |
dc.subject | pyridine derivative | en |
dc.subject | Pyridines | en |
dc.subject | Probes | en |
dc.subject | Coordination Complexes | en |
dc.subject | coordination compound | en |
dc.subject | Biochemistry | en |
dc.subject | DNA cleavage | en |
dc.subject | fluorescent dye | en |
dc.subject | Fluorescent Dyes | en |
dc.subject | Anticancer drug | en |
dc.subject | Bioinorganic chemistry | en |
dc.subject | macrocyclic compound | en |
dc.subject | DNA sequences | en |
dc.subject | Drug interactions | en |
dc.subject | G-quadruplex DNA | en |
dc.subject | G-quadruplexes | en |
dc.subject | guanine quadruplex | en |
dc.subject | Macrocyclic Compounds | en |
dc.subject | Medical chemistry | en |
dc.subject | Metal complexes | en |
dc.subject | Molecular probes | en |
dc.subject | Oncogenic viruses | en |
dc.subject | perylene | en |
dc.title | Interaction of metal complexes with G-quadruplex DNA | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/anie.200906363 | |
dc.description.volume | 49 | |
dc.description.issue | 24 | |
dc.description.startingpage | 4020 | |
dc.description.endingpage | 4034 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :241</p> | en |
dc.source.abbreviation | Angew.Chem.Int.Ed. | en |
dc.contributor.orcid | Georgiades, Savvas N. [0000-0002-6106-9904] | |
dc.gnosis.orcid | 0000-0002-6106-9904 | |