Show simple item record

dc.contributor.authorGeorgiades, Savvas N.en
dc.contributor.authorAbd Karim, N. H.en
dc.contributor.authorSuntharalingam, K.en
dc.contributor.authorVilar, R.en
dc.creatorGeorgiades, Savvas N.en
dc.creatorAbd Karim, N. H.en
dc.creatorSuntharalingam, K.en
dc.creatorVilar, R.en
dc.date.accessioned2019-11-21T06:19:05Z
dc.date.available2019-11-21T06:19:05Z
dc.date.issued2010
dc.identifier.issn1433-7851
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55491
dc.description.abstract[Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several key biological processes. In the human genome, guanine-rich sequences with the potential to form G-quadruplexes exist in the telomere as well as in promoter regions of certain oncogenes. The identification of these sequences as novel targets for the development of anticancer drugs has sparked great interest in the design of molecules that can interact with quadruplex DNA. While most reported quadruplex DNA binders are based on purely organic templates, numerous metal complexes have more recently been shown to interact effectively with this DNA secondary structure. This Review provides an overview of the important roles that metal complexes can play as quadruplex DNA binding molecules, highlighting the unique properties metals can confer to these molecules. © 2010 Wiley-VCH Verlag GmbH & Co. KCaA,.en
dc.sourceAngewandte Chemie - International Editionen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77953111689&doi=10.1002%2fanie.200906363&partnerID=40&md5=c81ea7ac0a2ac16ab733e83d1a3532dd
dc.subjectantineoplastic agenten
dc.subjectAntineoplastic Agentsen
dc.subjectreviewen
dc.subjectGenesen
dc.subjectDNAen
dc.subjectchemistryen
dc.subjectPositive ionsen
dc.subjectMetalsen
dc.subjectMoleculesen
dc.subjectComplexationen
dc.subjectpyridine derivativeen
dc.subjectPyridinesen
dc.subjectProbesen
dc.subjectCoordination Complexesen
dc.subjectcoordination compounden
dc.subjectBiochemistryen
dc.subjectDNA cleavageen
dc.subjectfluorescent dyeen
dc.subjectFluorescent Dyesen
dc.subjectAnticancer drugen
dc.subjectBioinorganic chemistryen
dc.subjectmacrocyclic compounden
dc.subjectDNA sequencesen
dc.subjectDrug interactionsen
dc.subjectG-quadruplex DNAen
dc.subjectG-quadruplexesen
dc.subjectguanine quadruplexen
dc.subjectMacrocyclic Compoundsen
dc.subjectMedical chemistryen
dc.subjectMetal complexesen
dc.subjectMolecular probesen
dc.subjectOncogenic virusesen
dc.subjectperyleneen
dc.titleInteraction of metal complexes with G-quadruplex DNAen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1002/anie.200906363
dc.description.volume49
dc.description.issue24
dc.description.startingpage4020
dc.description.endingpage4034
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :241</p>en
dc.source.abbreviationAngew.Chem.Int.Ed.en
dc.contributor.orcidGeorgiades, Savvas N. [0000-0002-6106-9904]
dc.gnosis.orcid0000-0002-6106-9904


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record