dc.contributor.author | Urgut, O. S. | en |
dc.contributor.author | Ozturk, I. I. | en |
dc.contributor.author | Banti, Christina N. | en |
dc.contributor.author | Kourkoumelis, Nikolaos | en |
dc.contributor.author | Manoli, Maria | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Hadjikakou, Sotiris K. | en |
dc.creator | Urgut, O. S. | en |
dc.creator | Ozturk, I. I. | en |
dc.creator | Banti, Christina N. | en |
dc.creator | Kourkoumelis, Nikolaos | en |
dc.creator | Manoli, Maria | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Hadjikakou, Sotiris K. | en |
dc.date.accessioned | 2019-11-21T06:23:26Z | |
dc.date.available | 2019-11-21T06:23:26Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/56266 | |
dc.description.abstract | Antimony(III) halide complexes of the formulae {[SbBr(Me2DTC)2]n} (1), {[SbI(Me2DTC)2]n} (2) and {[(Me2DTC)2Sb(μ2-I)Sb(Me2DTC)2]+.I3-} (3) (Me2DTC = dimethyldithiocarbomate) were synthesized from SbX3, (X = Br or I) and tetramethylthiuram monosulfide (Me4tms) or tetramethylthiuram disulfide (Me4tds). The complexes were characterized by melting point (m.p.), elemental analysis (e.a.), Fourier-transform Infra-Red (FT-IR), Fourier-transform Raman (FT-Raman), Nuclear Magnetic Resonance (1H,13C-NMR) spectroscopy and Thermogravimetric-Differential Thermal Analysis (TG-DTA). Crystal structures of complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1 and 2 are polymers with distorted square pyramidal (SP) geometry in each monomeric unit, whereas complex 3 is ionic, containing an iodonium linkage Sb-I+-Sb and an I3- counter anion | en |
dc.description.abstract | to the best of our knowledge, this is the first ionic antimony(III) iodide complex. The in vitro cytotoxic activity of 1-3 against human adenocarcinoma cells: breast (MCF-7) and cervix (HeLa) cells and non-cancerous cells: MRC-5 (normal human fetal lung fibroblast cells) was evaluated with trypan blue (TB) and sulforhodamine B (SRB) assays. Among antimony(III) compounds with sulfur containing ligand, those of dithiocarbamates exhibit significant cytotoxic activity. Hirshfeld surface volumes were analyzed to clarify the nature of the intermolecular interactions by the 2D fingerprint plot. Molecules with lower H-all atoms inter-molecular interactions exhibit the higher activity against MCF-7 cells. The in vivo genotoxicity of 1-3 was evaluated by the mean of Allium cepa test. Alterations in the mitotic index values due to the chromosomal aberrations were observed in the case of complexes 2 and 3. Since, no such alteration is caused by 1, it makes this compound candidate for further study as potential drug. © 2015 Elsevier B.V. All rights reserved. | en |
dc.source | Materials Science and Engineering C | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941117450&doi=10.1016%2fj.msec.2015.08.030&partnerID=40&md5=a11f2ee5e60086d4dcebaf6196c65770 | |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | cell survival | en |
dc.subject | cell death | en |
dc.subject | Chromosome Aberrations | en |
dc.subject | chromosome aberration | en |
dc.subject | chemistry | en |
dc.subject | drug effects | en |
dc.subject | Cytotoxicity | en |
dc.subject | Cells | en |
dc.subject | Cytology | en |
dc.subject | Synthesis (chemical) | en |
dc.subject | synthesis | en |
dc.subject | Nuclear magnetic resonance spectroscopy | en |
dc.subject | Molecules | en |
dc.subject | X ray diffraction analysis | en |
dc.subject | Thermoanalysis | en |
dc.subject | Single crystals | en |
dc.subject | Magnetic Resonance Spectroscopy | en |
dc.subject | X ray crystallography | en |
dc.subject | antimony | en |
dc.subject | temperature | en |
dc.subject | MCF-7 Cells | en |
dc.subject | Antimony compounds | en |
dc.subject | Ligands | en |
dc.subject | infrared spectroscopy | en |
dc.subject | Cell culture | en |
dc.subject | Thermogravimetric analysis | en |
dc.subject | ligand | en |
dc.subject | Differential thermal analysis | en |
dc.subject | hydrogen bond | en |
dc.subject | Nuclear magnetic resonance | en |
dc.subject | Molecular Conformation | en |
dc.subject | Fourier transform infra reds | en |
dc.subject | conformation | en |
dc.subject | Inhibitory Concentration 50 | en |
dc.subject | Crystallography, X-Ray | en |
dc.subject | HeLa Cells | en |
dc.subject | HeLa cell line | en |
dc.subject | Molecular structure | en |
dc.subject | Intermolecular interactions | en |
dc.subject | halogen | en |
dc.subject | MCF 7 cell line | en |
dc.subject | Spectroscopy, Fourier Transform Infrared | en |
dc.subject | Raman spectrometry | en |
dc.subject | Spectrum Analysis, Raman | en |
dc.subject | vibration | en |
dc.subject | Antimony(III) halide complexes | en |
dc.subject | Hydrogen Bonding | en |
dc.subject | Allium | en |
dc.subject | Biomaterials | en |
dc.subject | diethyldithiocarbamic acid | en |
dc.subject | Ditiocarb | en |
dc.subject | Genotoxicities | en |
dc.subject | Genotoxicity | en |
dc.subject | Halide complexes | en |
dc.subject | Halogens | en |
dc.subject | IC50 | en |
dc.subject | Metal halides | en |
dc.subject | mutagenic agent | en |
dc.subject | Mutagens | en |
dc.subject | Single crystal X-ray diffraction analysis | en |
dc.subject | Tetramethylthiuram disulfide | en |
dc.subject | Thermogravimetric-differential thermal analysis | en |
dc.subject | thiram | en |
dc.subject | Thiuram sulfides | en |
dc.title | New antimony(III) halide complexes with dithiocarbamate ligands derived from thiuram degradation: The effect of the molecule's close contacts on in vitro cytotoxic activity | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.msec.2015.08.030 | |
dc.description.volume | 58 | |
dc.description.startingpage | 396 | |
dc.description.endingpage | 408 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :12</p> | en |
dc.source.abbreviation | Mater.Sci.Eng.C | en |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Hadjikakou, Sotiris K. [0000-0001-9556-6266] | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0001-9556-6266 | |