Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences: Recent submissions
Now showing items 1-20 of 37
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Master Thesis Open Access
“Evaluation of the deep root training tube system’s performance under different drought stress conditions for 13 native plant species to Cyprus.
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)Climate change and desertification significantly threaten the Eastern Mediterranean, especially Cyprus. The island is experiencing a rise in average temperature and a significant decrease in the percentage of annual average ...
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Master Thesis Open Access
Common Myna (Acridotheres tristis) in Cyprus: mapping spread, control methods and impacts on birds globally.
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05-20)The Common Myna (Acridotheres tristis) stands as one of the most important avian invaders on a global scale, its presence extending across diverse ecosystems and continents. With its range continually expanding, the Common ...
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Master Thesis
Stumps and Lipin in the Drosophila midgut enteroendocrine cells independently regulate intestinal regeneration and permeability
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024-05)Leaky Gut Syndrome is a condition characterised by increased intestinal permeability that may lead to increased flow of lumen contents, such as nutrients, biomolecules, toxins, microbes, and chemicals, into the ...
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Master Thesis Open Access
The PINK1/Parkin-dependent mitophagy pathway and its role in Parkinson’s disease
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)Parkinson's disease is the second most prevalent neurodegenerative disease, surpassed only by Alzheimer’s disease. The disease is relentless, progressive, and incurable, and there is a great need to understand its causes ...
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Master Thesis Open Access
Prostate Cancer Organoids in the Fight Against Prostate Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)Ο καρκίνος του προστάτη είναι μία από τις κυριότερες ασθένειες που αυξάνουν τα ποσοστά νοσηρότητας και θνησιμότητας στους άνδρες παγκοσμίως. Παρά τη µεγάλη ετερογένεια µεταξύ των όγκων και των ασθενών, ο καρκίνος του ...
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Master Thesis Open Access
Novel therapeutic approaches targeting the molecular mechanisms governing SARS-CoV-2 infection
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing worldwide pandemic of Coronavirus Disease 2019 (COVID-19), which remains a public health concern despite the successful ...
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Master Thesis Open Access
Mechanisms underlying Trastuzumab Resistance in HER2-positive (HER2+) Breast Cancer and potential therapeutic approaches
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)HER2-positive (HER2+) breast cancer is characterized by overexpression of HER2 (Human Epidermal Growth Factor Receptor 2) protein on the surface of cells in the breast's ducts or lobes. HER2 overexpression creates an ...
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Master Thesis Open Access
MicroRNAs in Alzheimer's Disease: A Comprehensive Analysis and Therapeutic Implications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)Alzheimer's disease (AD) remains an enigmatic challenge in the field of neurodegenerative disorders, characterized by progressive cognitive decline and the accumulation of aberrant protein aggregates in the brain. This ...
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Master Thesis Open Access
EZH2: Role in breast cancer and potential therapeutic applications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)Human diseases, most notably cancer, are frequently associated with epigenetic dysregulation. Epigenetic modifications control gene function beyond the underlying sequence and are heritable but reversible alterations in ...
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Master Thesis Open Access
Extracellular Regulated Kinase (ERK): A novel regulator in the development and function of cilia
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-06-14)The role of cilia in biomedicine is becoming more and more recognized since defects in ciliary structure and function induce ciliopathies such as cystic kidney disease, neurological anomalies, obesity, blindness, and ...
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Master Thesis Open Access
Quantifying the fragmentation levels of amphibian, reptile, and terrestrial mammal habitats inside and outside of Natura 2000 sites within the European Union
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-25)Natural landscapes are constantly being modified and fragmented through a plethora of human activities, such as urbanisation and agriculture. Landscape fragmentation can have multiple negative effects on biodiversity. For ...
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Master Thesis Open Access
Investigating the role of Methyl CpG Binding proteins in Cervical Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-12)DNA methylation (5mC) is one of the main epigenetic modifications that drive gene regulation. Methyl CpG binding proteins (MBDs) bind methylated DNA and recruit the nucleosome remodelling and deacetylase complex (Nurd) ...
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Master Thesis
Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-24)NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...
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Master Thesis
Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-28)N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...
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Master Thesis Open Access
Molecular pathways affected by HBx protein and their targeting for therapy of Hepatocellular carcinoma
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-09)Hepatitis B virus (HBV) infection can cause several types of liver disease including acute hepatitis, chronic hepatitis, and liver cirrhosis. It is also considered a significant risk factor for Hepatocellular carcinoma ...
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Master Thesis Open Access
The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-18)Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...
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Master Thesis Open Access
Investigation of the role of cytoskeleton protein KATNAL2 in ribosomal gene transcription in mouse cells
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-23)The discovery that katanin-like cytoskeleton protein KATNAL2, in addition to its intracellular localization at MTs and sites associated with MTs (centrioles, cilia), also, unexpectedly, resides in the nucleolus, suggests ...
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Master Thesis Open Access
Novel molecular approaches to treat colorectal cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...
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Master Thesis
Development of a de novo Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection and Discrimination of SARS-CoV-2 Variants of Concern
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-16)The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and is the causative agent of the Coronavirus Disease 2019 (COVID-19). Since its emergence it has led to a global pandemic with devastating ...
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Master Thesis Open Access
Mechanical Cell Membrane stimulation using Magnetic Tweezers increases cell membrane stiffness through integrin dependent and independent mechanisms
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)Several cellular processes, such as proliferation, migration tissue morphogenesis and tissue regeneration, are closely regulated by the cells ability to sense their microenvironment and translate mechanical stimuli to ...