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dc.contributor.authorDeoni,Sean C. L.en
dc.contributor.authorZinkstok, J. R.en
dc.contributor.authorDaly,Eileen M.en
dc.contributor.authorEcker,C.en
dc.contributor.authorWilliams,Steven C. R.en
dc.contributor.authorMurphy,Declan G. M.en
dc.contributor.authorBailey, Anthony J.en
dc.contributor.authorBaron-Cohen,Simonen
dc.contributor.authorBolton, P. F.en
dc.contributor.authorBullmore,Edward T.en
dc.contributor.authorCarrington, S.en
dc.contributor.authorChakrabarti,B.en
dc.contributor.authorDaly,Eileen M.en
dc.contributor.authorDeoni,Sean C. L.en
dc.contributor.authorEcker,C.en
dc.contributor.authorHappé,Francescaen
dc.contributor.authorHenty, Julianen
dc.contributor.authorJezzard, Peteren
dc.contributor.authorJohnston,Patricken
dc.contributor.authorJones, D. K.en
dc.contributor.authorLombardo,Michael V.en
dc.contributor.authorMadden, A.en
dc.contributor.authorMullins, D.en
dc.contributor.authorMurphy,Clodagh M.en
dc.contributor.authorMurphy,Declan G. M.en
dc.contributor.authorPasco, Gregen
dc.contributor.authorSadek,Susan A.en
dc.contributor.authorSpain,D.en
dc.contributor.authorSteward, R.en
dc.contributor.authorSuckling,Johnen
dc.contributor.authorWheelwright,Sally J.en
dc.contributor.authorWilliams,Steven C. R.en
dc.creatorDeoni,Sean C. L.en
dc.creatorZinkstok, J. R.en
dc.creatorDaly,Eileen M.en
dc.creatorEcker,C.en
dc.creatorWilliams,Steven C. R.en
dc.creatorMurphy,Declan G. M.en
dc.creatorBailey, Anthony J.en
dc.creatorBaron-Cohen,Simonen
dc.creatorBolton, P. F.en
dc.creatorBullmore,Edward T.en
dc.creatorCarrington, S.en
dc.creatorChakrabarti,B.en
dc.creatorDaly,Eileen M.en
dc.creatorDeoni,Sean C. L.en
dc.creatorEcker,C.en
dc.creatorHappé,Francescaen
dc.creatorHenty, Julianen
dc.creatorJezzard, Peteren
dc.creatorJohnston,Patricken
dc.creatorJones, D. K.en
dc.creatorLombardo,Michael V.en
dc.creatorMadden, A.en
dc.creatorMullins, D.en
dc.creatorMurphy,Clodagh M.en
dc.creatorMurphy,Declan G. M.en
dc.creatorPasco, Gregen
dc.creatorSadek,Susan A.en
dc.creatorSpain,D.en
dc.creatorSteward, R.en
dc.creatorSuckling,Johnen
dc.creatorWheelwright,Sally J.en
dc.creatorWilliams,Steven C. R.en
dc.date.accessioned2017-07-27T10:21:37Z
dc.date.available2017-07-27T10:21:37Z
dc.date.issued2015
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/37229
dc.description.abstractBackground. Increasing evidence suggests that autism is associated with abnormal white-matter (WM) anatomy and impaired brain 'connectivity'. While myelin plays a critical role in synchronized brain communication, its aetiological role in autistic symptoms has only been indirectly addressed by WM volumetric, relaxometry and diffusion tensor imaging studies. A potentially more specific measure of myelin content, termed myelin water fraction (MWF), could provide improved sensitivity to myelin alteration in autism. Method. We performed a cross-sectional imaging study that compared 14 individuals with autism and 14 age- and IQ-matched controls. T1 relaxation times (T1), T2 relaxation times (T2) and MWF values were compared between autistic subjects, diagnosed using the Autism Diagnostic Interview - Revised (ADI-R), with current symptoms assessed using the Autism Diagnostic Observation Schedule (ADOS) and typical healthy controls. Correlations between T1, T2 and MWF values with clinical measures ADI-R, ADOS, and the Autism Quotient (AQ)] were also assessed. Results. Individuals with autism showed widespread WM T1 and MWF differences compared to typical controls. Within autistic individuals, worse current social interaction skill as measured by the ADOS was related to reduced MWF although not T1. No significant differences or correlations with symptoms were observed with respect to T2. Conclusions. Autistic individuals have significantly lower global MWF and higher T1, suggesting widespread alteration in tissue microstructure and biochemistry. Areas of difference, including thalamic projections, cerebellum and cingulum, have previously been implicated in the disorder; however, this is the first study to specifically indicate myelin alteration in these regions. Copyright © 2014 Cambridge University Press.en
dc.sourcePsychological medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84927695839&doi=10.1017%2fS0033291714001858&partnerID=40&md5=aabf92daf8a067d05fabf16bb11cf253
dc.subjectAutismen
dc.subjectBrain connectivityen
dc.subjectBrain developmenten
dc.subjectHuman brain imagingen
dc.subjectMyelinen
dc.subjectWhite matteren
dc.titleWhite-matter relaxation time and myelin water fraction differences in young adults with autismen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1017/S0033291714001858
dc.description.volume45
dc.description.issue4
dc.description.startingpage795
dc.description.endingpage805
dc.author.facultyΣχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and Education
dc.author.departmentΤμήμα Ψυχολογίας / Department of Psychology
dc.type.uhtypeArticleen
dc.description.notesCited By :8; Export Date: 17 July 2017en
dc.source.abbreviationPsychol.Med.en
dc.contributor.orcidLombardo, Michael V. [0000-0001-6780-8619]


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