Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title
Now showing items 618-637 of 677
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Article
Therapeutic monitoring of continuous infusion etoposide in small-cell lung cancer
(1996)Purpose: To investigate the feasibility of therapeutic monitoring of etoposide at different plasma concentrations of the drug, and the resulting pharmacodynamic effects of such an approach. Patients and Methods: Forty- ...
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Thin basement membrane nephropathy: Is there genetic predisposition to more severe disease?
(2009)
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Tissue communication in regenerative inflammatory signaling: Lessons from the fly gut
(2014)The intestine, as a barrier epithelium, serves in the first line of defense against invading pathogens and damaging agents that enter the body via food ingestion. Maintenance of intestinal homeostasis is therefore key to ...
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Article
Topologically constrained domains of supercoiled DNA in eukaryotic cells
(1997)The size of supercoiled, topologically constrained DNA domains within the squamous carcinoma cell line SQ-20B were determined by direct comparison with a panel of irradiated supercoiled plasmid DNAs. Loss of supercoiling ...
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A translation frameshift mutation induced by a cytosine insertion in the Polycystic Kidney Disease 2 gene (PKD2)
(1997)Mutations in the PKD2 gene on the long arm of chromosome 4 are responsible for ~ 15% of cases of polycystic kidney disease. Perhaps the only difference from the more common ADPKD1 cases is the rate of progression of cystic ...
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Transmission of drug-resistant HIV-1 is stabilizing in Europe
(2009)The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed ...
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Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe
(2016)Background. Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial ...
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Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients
(2012)Background: The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, ...
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Trends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemic
(2014)We aimed to study epidemic trends and predictors for transmitted drug resistance (TDR) in our region, its clinical impact and its association with transmission clusters. We included 778 patients from the AIDS Reference ...
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Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats
(2002)Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones ...
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Trophoblast-specific gene manipulation using lentivirus-based vectors
(2007)The trophoblast layers of the mammalian placenta carry out many complex functions required to pattern the developing embryo and maintain its growth and survival in the uterine environment. Genetic disruption of many gene ...
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Turnover of plants on small islets of the eastern Aegean Sea within two decades
(2008)Aim: To estimate species turnover of plants on 32 small islands within a 20-year period and to assess possible changes in community composition and properties, such as species richness and factors affecting it, nestedness, ...
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Type I procollagen: The gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue
(1989)Recent data from several laboratories have established that most variants of osteogenesis imperfecta (OI) are caused by mutations in the 2 structural genes for type I procollagen. There are 2 general reasons for the large ...
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Ultraviolet Absorbance and Circular Dichroism of Pf1 Virus: Nucleotide/Subunit Ratio of Unity, Hyperchromic Tyrosines and DNA Bases, and High Helicity in the Subunits
(1994)Data have been obtained for the Pfl virion that establish its stoichiometry and conformational features of its DNA and its protein. The absorbance spectrum of the dissociated virus under alkaline denaturing conditions is ...
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Book Chapter
The unknown caspase: The role of caspase-14 in cell death and disease
(Nova Science Publishers, Inc., 2016)Caspase-14 is unique among caspase family proteases. It is the shortest member of the caspase family that was first described as a developmentally regulated protease due to its high expression in embryonic tissues. Based ...
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Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits
(2019)Physiology, fitness and disease phenotypes are complex traits exhibiting continuous variation in natural populations. To understand complex trait gene functions transgenic lines of undefined genetic background are often ...
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An updated view of the oligosaccharyltransferase complex in Plasmodium
(2019)Abstract. Despite the controversy regarding the importance of protein N-linked glycosylation in species of the genus Plasmodium, genes potentially encoding cor
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