Transmission of drug-resistant HIV-1 is stabilizing in Europe
Date
2009Author
Vercauteren, J.Wensing, A. M. J.
Van De Vijver, D. A. M. C.
Albert, Jan
Balotta, Claudia
Hamouda, O.
Kücherer, C.
Struck, D.
Schmit, J. -C
Åsjö, Birgitta
Bruckova, M.
Camacho, Ricardo J.
Clotet, B.
Coughlan, S.
Grossman, Z.
Horban, A.
Korn, K.
Kostrikis, Leontios G.
Nielsen, C.
Paraskevis, Dimitrios N.
Poljak, M.
Puchhammer-Stöckl, E.
Riva, C.
Ruiz, L.
Salminen, M.
Schuurman, R.
Sonnerborg, A.
Stanekova, D.
Stanojevic, M.
Vandamme, A. M.
Boucher, C. A. B.
Source
Journal of Infectious DiseasesVolume
200Pages
1503-1508Google Scholar check
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Show full item recordAbstract
The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (Pp.04) and in NNRTI resistance after an initial increase (Pp.02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection. © 2009 by the Infectious Diseases Society of America. All rights reserved.
DOI
10.1086/644505Collections
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