dc.contributor.author | Stoyianni, A. | en |
dc.contributor.author | Pentheroudakis, George | en |
dc.contributor.author | Benjamin, H. | en |
dc.contributor.author | Cervantes, A. | en |
dc.contributor.author | Ashkenazi, K. | en |
dc.contributor.author | Lazaridis, G. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Spector, Y. | en |
dc.creator | Stoyianni, A. | en |
dc.creator | Pentheroudakis, George | en |
dc.creator | Benjamin, H. | en |
dc.creator | Cervantes, A. | en |
dc.creator | Ashkenazi, K. | en |
dc.creator | Lazaridis, G. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Spector, Y. | en |
dc.date.accessioned | 2018-06-22T09:53:17Z | |
dc.date.available | 2018-06-22T09:53:17Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41751 | |
dc.description.abstract | Purpose: We sought to study the microRNA regulation of epithelial mesenchymal transition (EMT), the acquisition of migratory, mesenchymal-like properties of epithelial cells, in cancer of unknown primary (CUP). Patients and methods: We studied the global expression profile of 982 microRNAs by means of microarray technology in 68 CUP cases immunohistochemically characterised as EMT-positive (n = 5 by % of cells or n = 10 by a semiquantitative H-score) or EMT-negative. Results: EMT-suppressive miRNAs such as miR-203 and members of the miR-200 family (miR-200a,b,c and miR-141) presented a 2.45 to 3.64-fold lower expression level in the EMT-positive cases without, however, reaching statistical significance. MiR-205, a squamous tissue-specific marker, was very variable in the data set. Excluding CUP cases with squamous cell histology, miR-205, miR-203 and the miR-200 family exhibited a trend of downregulation in EMT-positive cases. A similar pattern of miRNA expression was detected when the comparison took place between EMT-positive vs EMT-negative cases according to the H-score. Moreover, miR-203, miR-205 and miR-200c were numerically downregulated in those tumours with high expression of the EMT marker N-cadherin. Conclusions: The EMT-suppressive miR-203 and miR-200 family were consistently but non-significantly downregulated in CUP with the EMT phenotype. A larger study is warranted to further explore the role of microRNAs in CUP. © 2013 Federación de Sociedades Españolas de Oncología (FESEO). | en |
dc.language.iso | eng | en |
dc.source | Clinical and Translational Oncology | en |
dc.subject | Article | en |
dc.subject | Cancer chemotherapy | en |
dc.subject | Human | en |
dc.subject | Neoplasms | en |
dc.subject | 80 and over | en |
dc.subject | Aged | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Cancer survival | en |
dc.subject | Human tissue | en |
dc.subject | Overall survival | en |
dc.subject | Male | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Protein expression | en |
dc.subject | Unclassified drug | en |
dc.subject | Histopathology | en |
dc.subject | Upregulation | en |
dc.subject | Middle aged | en |
dc.subject | Cancer of unknown primary site | en |
dc.subject | Unknown primary | en |
dc.subject | Metastasis | en |
dc.subject | Phenotype | en |
dc.subject | Human cell | en |
dc.subject | Microarray analysis | en |
dc.subject | Microrna | en |
dc.subject | Microrna 200c | en |
dc.subject | Genetics | en |
dc.subject | Cancer of unknown primary | en |
dc.subject | Tissue microarray | en |
dc.subject | Very elderly | en |
dc.subject | Micrornas | en |
dc.subject | Nerve cell adhesion molecule | en |
dc.subject | Transcription factor snail | en |
dc.subject | Uvomorulin | en |
dc.subject | Epithelial mesenchymal transition | en |
dc.subject | Epithelial-mesenchymal transition | en |
dc.subject | Microrna 141 | en |
dc.subject | Microrna 200a | en |
dc.subject | Microrna 200b | en |
dc.subject | Microrna 203 | en |
dc.subject | Microrna 205 | en |
dc.title | Insights into the epithelial mesenchymal transition phenotype in cancer of unknown primary from a global microRNA profiling study | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s12094-013-1139-5 | |
dc.description.volume | 16 | |
dc.description.issue | 8 | |
dc.description.startingpage | 725 | |
dc.description.endingpage | 731 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Pentheroudakis, George [0000-0002-6632-2462] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-6632-2462 | |