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dc.contributor.authorTsantes, Argirio E.en
dc.contributor.authorTsangaris, I.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorBagos, Pantelis G.en
dc.contributor.authorKopterides, Petrosen
dc.contributor.authorAntonakos, Georgiosen
dc.contributor.authorDimopoulou, Ioannaen
dc.contributor.authorVrioni, G.en
dc.contributor.authorKapsimali, Violettaen
dc.contributor.authorDima, Kleanthien
dc.contributor.authorArmaganidis, Apostolosen
dc.contributor.authorTravlou, Anthi S.en
dc.creatorTsantes, Argirio E.en
dc.creatorTsangaris, I.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorBagos, Pantelis G.en
dc.creatorKopterides, Petrosen
dc.creatorAntonakos, Georgiosen
dc.creatorDimopoulou, Ioannaen
dc.creatorVrioni, G.en
dc.creatorKapsimali, Violettaen
dc.creatorDima, Kleanthien
dc.creatorArmaganidis, Apostolosen
dc.creatorTravlou, Anthi S.en
dc.date.accessioned2018-06-22T09:53:21Z
dc.date.available2018-06-22T09:53:21Z
dc.date.issued2010
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41795
dc.description.abstractBackground. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis of sepsis. The protein C pathway has been reported to play a central role both in the propagation of sepsis and a hyperhomocysteinemia-induced hypercoagulable state. Our primary aim was to measure plasma homocysteine levels in mechanically ventilated patients with severe sepsis/septic shock and to assess the association of these levels with relevant clinical outcomes. Methods. The study cohort included 102 mechanically ventilated patients with severe sepsis or septic shock. Demographics, comorbidities, clinical data and severity scores were recorded. Plasma homocysteine, vitamin B12, folate, creatinine, and protein C levels were measured in all study subjects upon enrollment, and genotyping for the C677T and A1298C polymorphisisms of the methylenetetrahydrofolate reductase (MTHFR) gene and for factor V Leiden (FVL) mutations was performed as well. The primary outcomes were mortality at 28 and 90 days; secondary outcomes included the number of days without renal or cardiovascular failure and the ventilator-free days during the study period. Results. Homocysteine levels were not significantly associated with any primary or secondary outcomes in the multivariable analysis. In addition, a synergistic effect of homocysteine with protein C levels was not detected. Conclusion. Our data suggest that plasma homocysteine levels may not inform the prognosis of mechanically ventilated patients with severe sepsis/septic shock.en
dc.language.isoengen
dc.sourceMinerva anestesiologicaen
dc.subject5
dc.subjectArticleen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectPrognosisen
dc.subjectSurvival rateen
dc.subjectMaleen
dc.subjectMortalityen
dc.subjectSingle nucleotide polymorphismen
dc.subjectClinical assessmenten
dc.subjectBlood analysisen
dc.subjectCreatinineen
dc.subjectSeptic shocken
dc.subjectArtificialen
dc.subjectArtificial ventilationen
dc.subjectRespirationen
dc.subjectSepsisen
dc.subjectCritically ill patienten
dc.subjectHospital mortalityen
dc.subjectShocken
dc.subjectGene mutationen
dc.subjectComorbidityen
dc.subjectCohort studiesen
dc.subjectBlood coagulation testsen
dc.subjectGenetic variabilityen
dc.subject10 methylenetetrahydrofolate reductase (fadh2)en
dc.subjectCyanocobalaminen
dc.subjectFolic aciden
dc.subjectProtein cen
dc.subjectPoint mutationen
dc.subjectActivated protein c resistanceen
dc.subjectBlood clotting factor 5 leidenen
dc.subjectFactor ven
dc.subjectHomocysteineen
dc.subjectHomocystinuriaen
dc.subjectHyperhomocysteinemiaen
dc.subjectMethylenetetrahydrofolate reductase (nadph2)en
dc.subjectMuscle spasticityen
dc.subjectPsychotic disordersen
dc.subjectSepticen
dc.subjectThrombophiliaen
dc.subjectVitamin b 12en
dc.titleThe effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsisen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume76
dc.description.issue10
dc.description.startingpage787
dc.description.endingpage794
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]


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