dc.contributor.author | Voulgaris, E. | en |
dc.contributor.author | Pentheroudakis, George | en |
dc.contributor.author | Pappa, L. | en |
dc.contributor.author | Bafa, M. | en |
dc.contributor.author | Goussia, Anna | en |
dc.contributor.author | Dalezis, P. | en |
dc.contributor.author | Tsombanidou, C. | en |
dc.contributor.author | Geromichalos, G. | en |
dc.contributor.author | Papageorgiou, A. | en |
dc.contributor.author | Koutsilieris, M. | en |
dc.contributor.author | Malamou-Mitsi, Vassiliki D. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.creator | Voulgaris, E. | en |
dc.creator | Pentheroudakis, George | en |
dc.creator | Pappa, L. | en |
dc.creator | Bafa, M. | en |
dc.creator | Goussia, Anna | en |
dc.creator | Dalezis, P. | en |
dc.creator | Tsombanidou, C. | en |
dc.creator | Geromichalos, G. | en |
dc.creator | Papageorgiou, A. | en |
dc.creator | Koutsilieris, M. | en |
dc.creator | Malamou-Mitsi, Vassiliki D. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.date.accessioned | 2018-06-22T09:53:26Z | |
dc.date.available | 2018-06-22T09:53:26Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41836 | |
dc.description.abstract | Purpose: To study the phenomenon of positive urine cytology in patients with lung cancer in the absence of obvious urothelial metastases. Patients and methods: 150 patients with small (SCLC) and non-small cell lung cancer (NSCLC) of all stages and 3 control groups were prospectively studied. Immunocytochemical study (cytokeratins 7-20, TTF1) in all positive urine specimens and chemokine profile (CXCR4, CCL21) study of the primary tumor in selected positive patients was performed. In experimental study, C57Bl/6 BALB/C mice injected with LLC lung and 4T1 mammary cancer cells were used for the detection of positive urine cytology. Results: 11% of patients with NSCLC, 7% of patients with SCLC and none of the control group had positive urine cytology. In NSCLC, metastatic disease and high tumor burden positively correlated (p = 0.01 and 0.03 respectively) with the phenomenon. In SCLC, correlation with extensive disease and multiple metastatic sites (p = 0.02 and 0.04 respectively) was found. No correlation was found in either group with: age, gender, histology, performance status, line of chemotherapy, previous platinum-based chemotherapy, adrenal metastases, renal function, abnormal urinary sediment, response to chemotherapy and overall survival (p = 0.9). Distinctive chemokine expression was identified in positive patients studied and was not observed in negative patients (×2 p = 0.008). In the experimental study, only the LLC lung cancer cells were detected in the urine cytology of mice. Conclusion: This phenomenon, carrying undefined pathophysiological mechanisms, seems to characterize only patients with metastatic/extensive disease and high tumor burden. Further studies are needed to validate our preliminary chemokine expression results. © 2010 Elsevier Ireland Ltd. | en |
dc.language.iso | eng | en |
dc.source | Lung Cancer | en |
dc.subject | Article | en |
dc.subject | Adult | en |
dc.subject | Female | en |
dc.subject | Human | en |
dc.subject | 80 and over | en |
dc.subject | Aged | en |
dc.subject | Humans | en |
dc.subject | Transplantation | en |
dc.subject | Breast cancer | en |
dc.subject | Controlled study | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Neoplasm staging | en |
dc.subject | Priority journal | en |
dc.subject | Tumor volume | en |
dc.subject | Human tissue | en |
dc.subject | Platinum | en |
dc.subject | Cancer staging | en |
dc.subject | Lung neoplasms | en |
dc.subject | Lung non small cell cancer | en |
dc.subject | Lung small cell cancer | en |
dc.subject | Overall survival | en |
dc.subject | Case-control studies | en |
dc.subject | Carcinoma | en |
dc.subject | Disease course | en |
dc.subject | Male | en |
dc.subject | Correlation analysis | en |
dc.subject | Protein expression | en |
dc.subject | Receptors | en |
dc.subject | Histopathology | en |
dc.subject | Nonhuman | en |
dc.subject | Adrenal metastasis | en |
dc.subject | Lung cancer | en |
dc.subject | Treatment response | en |
dc.subject | Tumor localization | en |
dc.subject | Pathophysiology | en |
dc.subject | Cytokeratin | en |
dc.subject | Immunocytochemistry | en |
dc.subject | Kidney function | en |
dc.subject | Validation process | en |
dc.subject | Cancer cell | en |
dc.subject | Human cell | en |
dc.subject | Non-small-cell lung | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | Animal cell | en |
dc.subject | Animal experiment | en |
dc.subject | Animal model | en |
dc.subject | Animal tissue | en |
dc.subject | Mouse | en |
dc.subject | Inbred balb c | en |
dc.subject | Urine cytology | en |
dc.subject | Urine sediment | en |
dc.subject | Urologic neoplasms | en |
dc.subject | Primary tumor | en |
dc.subject | Occult | en |
dc.subject | Small cell lung carcinoma | en |
dc.subject | Cxcr4 | en |
dc.subject | Experimental | en |
dc.subject | Chemokine receptor cxcr4 | en |
dc.subject | Chemokine | en |
dc.subject | Chemokine ccl21 | en |
dc.subject | Heterologous | en |
dc.subject | Inbred c57bl | en |
dc.subject | Lewis lung | en |
dc.subject | Mammary neoplasms | en |
dc.subject | Neoplasm transplantation | en |
dc.subject | Secondary lymphoid tissue chemokine | en |
dc.subject | Urinary tract tumor | en |
dc.subject | Urothelial metastases | en |
dc.title | Positive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastases | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.lungcan.2010.10.018 | |
dc.description.volume | 73 | |
dc.description.issue | 1 | |
dc.description.startingpage | 51 | |
dc.description.endingpage | 58 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Pentheroudakis, George [0000-0002-6632-2462] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-6632-2462 | |