Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis
dc.contributor.author | Wozniak, Greta | en |
dc.contributor.author | Toska, Aikaterini | en |
dc.contributor.author | Saridi, Maria | en |
dc.contributor.author | Mouzas, Odysseas | en |
dc.creator | Wozniak, Greta | en |
dc.creator | Toska, Aikaterini | en |
dc.creator | Saridi, Maria | en |
dc.creator | Mouzas, Odysseas | en |
dc.date.accessioned | 2018-06-22T09:53:31Z | |
dc.date.available | 2018-06-22T09:53:31Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41881 | |
dc.description.abstract | Selective serotonin reuptake inhibitors (SSRIs) are a class of drug widely used for treatment of mood disorders, including depression and cardiovascular disease. A search for related articles in the PubMed database was attempted. It covered studies, reports, reviews and editorials of the last 5 years. Pro-infammatory cytokines, such as TNF-a, IL-1 and IL-6, stimulate central serotonin (5-HT) neu-rotransmission and are over-expressed in depression, which has been linked with hypothalamic-pi-tuitary-adrenal axis (HPA) hyperactivity. They have also been implicated in the pathogenesis and progression of other stress-induced disorders, like myocardial infarction (MI) and coronary heart disease (CHD), as they seem to modulate cardiovascular function by a variety of mechanisms. Biological mechanisms like these may explain the link between depression and CHD. There are a variety of environmental factors as well as genetic factors that might infuence the pharmacoge-netics of antidepressant drugs. New generation selective serotonin reuptake inhibitor antidepres-sants (SSRIs) causing a reduced cardiovascular morbidity and mortality may be related to serotonin platelet abnormalities in depressed patients that are effectively treated by SSRIs. SSRIs such as fuoxetine, paroxetine, sertraline and citalopram are not only considered to be free from the cardiotoxicity of their predecessors but also to function as safe and effcacious agents against depression, platelet activation, atherosclerosis and development and prognosis of coronary heart disease. However, there is a need for more studies in order to establish the exact biochemical mechanisms that are responsible for these diseases and the immunoregulatory effects of chronic use of SSRI medications. © Med Sci Monit. | en |
dc.language.iso | eng | en |
dc.source | Medical Science Monitor | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Disease progression | en |
dc.subject | Drug safety | en |
dc.subject | Atherosclerosis | en |
dc.subject | Cardiovascular disease | en |
dc.subject | Gamma interferon | en |
dc.subject | Dna polymorphism | en |
dc.subject | Heart infarction | en |
dc.subject | Protein expression | en |
dc.subject | Cardiovascular risk | en |
dc.subject | Disease association | en |
dc.subject | Interleukin 10 | en |
dc.subject | Interleukin 1beta | en |
dc.subject | Interleukin 6 | en |
dc.subject | Major depression | en |
dc.subject | Nonhuman | en |
dc.subject | T lymphocyte | en |
dc.subject | Depression | en |
dc.subject | Long term care | en |
dc.subject | Low drug dose | en |
dc.subject | Antidepressive agents | en |
dc.subject | Paroxetine | en |
dc.subject | Syncope | en |
dc.subject | Immunoregulation | en |
dc.subject | Adaptive immunity | en |
dc.subject | Innate immunity | en |
dc.subject | Cytokine production | en |
dc.subject | Interleukin 4 | en |
dc.subject | Tumor necrosis factor alpha | en |
dc.subject | Cytokine release | en |
dc.subject | Blurred vision | en |
dc.subject | Ischemic heart disease | en |
dc.subject | Heart failure | en |
dc.subject | Corticotropin | en |
dc.subject | Heart arrhythmia | en |
dc.subject | Stroke | en |
dc.subject | Thrombocyte function | en |
dc.subject | Citalopram | en |
dc.subject | Serotonin | en |
dc.subject | Adiponectin | en |
dc.subject | Amfebutamone | en |
dc.subject | B lymphocyte | en |
dc.subject | Bradycardia | en |
dc.subject | Drowsiness | en |
dc.subject | Escitalopram | en |
dc.subject | Fluoxetine | en |
dc.subject | Hypothalamus hypophysis adrenal system | en |
dc.subject | Immune system | en |
dc.subject | Interleukin 1 | en |
dc.subject | Interleukin 12 | en |
dc.subject | Interleukin 13 | en |
dc.subject | Mirtazapine | en |
dc.subject | Obsessive compulsive disorder | en |
dc.subject | Orthostatic hypotension | en |
dc.subject | Ox40 ligand | en |
dc.subject | Panic | en |
dc.subject | Posttraumatic stress disorder | en |
dc.subject | Qt prolongation | en |
dc.subject | Serotonin uptake inhibitor | en |
dc.subject | Serotonin uptake inhibitors | en |
dc.subject | Sertraline | en |
dc.subject | Sexual dysfunction | en |
dc.subject | Social phobia | en |
dc.subject | Ssris | en |
dc.subject | Stable angina pectoris | en |
dc.subject | Thrombocyte activation | en |
dc.subject | Tnf-a | en |
dc.subject | Unstable angina pectoris | en |
dc.title | Serotonin reuptake inhibitor antidepressants (SSRIs) against atherosclerosis | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 17 | |
dc.description.issue | 9 | |
dc.description.startingpage | RA205 | |
dc.description.endingpage | RA214 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Wozniak, Greta [0000-0002-8939-0927] | |
dc.contributor.orcid | Saridi, Maria [0000-0002-9008-824X] | |
dc.gnosis.orcid | 0000-0002-8939-0927 | |
dc.gnosis.orcid | 0000-0002-9008-824X |
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