Show simple item record

dc.contributor.authorLazaridis, G.en
dc.contributor.authorPentheroudakis, Georgeen
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorPavlidis, Nicholasen
dc.creatorLazaridis, G.en
dc.creatorPentheroudakis, Georgeen
dc.creatorFountzilas, Georgeen
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:56Z
dc.date.available2018-06-22T09:53:56Z
dc.date.issued2008
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42105
dc.description.abstractAim: Patients with liver metastases from cancer of unknown primary (CUPL) have a dismal prognosis. We retrospectively analysed their management and outcome and performed a systematic review of CUPL series published in the literature. Patients and methods: Electronic data from 49 CUPL patients referred to Hellenic Cooperative Oncology Group (HeCOG) centers were retrospectively studied for characteristics of clinical presentation, diagnostic workup, management, outcome and prognostic factors. A systematic literature review was undertaken in PubMed and EmBase databases. Results: All our patients (males: 31, females: 18; median age: 65) underwent a computed tomography scan (CT) of the abdomen, 71% a thoracic CT, 53% gastroscopy and 47% colonoscopy. The commonest histologic subtypes encountered were adenocarcinoma (N = 34) or undifferentiated carcinoma (N = 12). The liver was the only metastatic site in 38% of patients, while it was accompanied with other metastatic sites in 62% (the commonest: lung, bone and lymph nodes). Forty-seven patients received first-line chemotherapy (42 platinum based) and 16 second-line. An objective response was observed in six patients (12%), median survival being 10 months (95% CI, 7-13). In univariate analysis, good performance status and normal baseline serum CEA levels were correlated with superior survival, while in multivariate analysis only age < 55 (HR 0.16, p = 0.02) and the absence of extrahepatic disease (HR 0.21, p = 0.007) predicted for a better outcome. Published data from four relevant series (total patients = 662) parallel our findings. Conclusions: Patients with liver metastases from CUP are resistant to conventional types of treatment and carry a poor prognosis. Understanding the molecular biology of CUP is essential for the development of new, targeted effective therapies. © 2008 Elsevier Ltd. All rights reserved.en
dc.language.isoengen
dc.sourceCancer treatment reviewsen
dc.subjectFluorouracilen
dc.subjectHumanen
dc.subjectNeoplasmsen
dc.subjectAdenocarcinomaen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectCarboplatinen
dc.subjectChemotherapyen
dc.subjectComputer assisted tomographyen
dc.subjectDrug responseen
dc.subjectNeoplasm stagingen
dc.subjectPrognosisen
dc.subjectRetrospective studiesen
dc.subjectRetrospective studyen
dc.subjectAnemiaen
dc.subjectAntineoplastic combined chemotherapy protocolsen
dc.subjectClinical trialen
dc.subjectControlled clinical trialen
dc.subjectFebrile neutropeniaen
dc.subjectNeutropeniaen
dc.subjectOxaliplatinen
dc.subjectSurvival analysisen
dc.subjectGastrointestinal toxicityen
dc.subjectSurvival rateen
dc.subjectReviewen
dc.subjectDocetaxelen
dc.subjectOverall survivalen
dc.subjectOutcome assessmenten
dc.subjectSurvivalen
dc.subjectSystematic reviewen
dc.subjectBone metastasisen
dc.subjectFolinic aciden
dc.subjectIrinotecanen
dc.subjectPlatinum complexen
dc.subjectCarcinomaen
dc.subjectMaleen
dc.subjectAge distributionen
dc.subjectLogistic modelsen
dc.subjectSex differenceen
dc.subjectClinical featureen
dc.subjectAnalysis of varianceen
dc.subjectImmunohistochemistryen
dc.subjectHistopathologyen
dc.subjectLymph node metastasisen
dc.subjectBlood toxicityen
dc.subjectProbabilityen
dc.subjectRisk assessmenten
dc.subjectSurvival timeen
dc.subjectLiteratureen
dc.subjectLiver neoplasmsen
dc.subjectLiver metastasisen
dc.subjectLung metastasisen
dc.subjectColonoscopyen
dc.subjectCancer of unknown primary siteen
dc.subjectUnknown primaryen
dc.subjectCarcinoembryonic antigenen
dc.subjectProtein blood levelen
dc.subjectCancer of unknown primaryen
dc.subjectMultivariate analysisen
dc.subjectCapecitabineen
dc.subjectCancer resistanceen
dc.subjectTomographyen
dc.subjectProportional hazards modelsen
dc.subjectBiopsyen
dc.subjectAbdominal scintiscanningen
dc.subjectEmbaseen
dc.subjectGastroscopyen
dc.subjectLiver metastasesen
dc.subjectLymph nodesen
dc.subjectMedlineen
dc.subjectNeedleen
dc.subjectThorax scintiscanningen
dc.subjectX-ray computeden
dc.titleLiver metastases from cancer of unknown primary (CUPL): A retrospective analysis of presentation, management and prognosis in 49 patients and systematic review of the literatureen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ctrv.2008.05.005
dc.description.volume34
dc.description.issue8
dc.description.startingpage693
dc.description.endingpage700
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record