dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Tsangaris, I. | en |
dc.contributor.author | Tsiara, Chrissa G. | en |
dc.contributor.author | Kopterides, Petros | en |
dc.contributor.author | Vaiopoulos, A. | en |
dc.contributor.author | Kapsimali, Violetta | en |
dc.contributor.author | Bonovas, Stefanos | en |
dc.contributor.author | Tsantes, Argirio E. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Tsangaris, I. | en |
dc.creator | Tsiara, Chrissa G. | en |
dc.creator | Kopterides, Petros | en |
dc.creator | Vaiopoulos, A. | en |
dc.creator | Kapsimali, Violetta | en |
dc.creator | Bonovas, Stefanos | en |
dc.creator | Tsantes, Argirio E. | en |
dc.date.accessioned | 2018-06-22T09:54:08Z | |
dc.date.available | 2018-06-22T09:54:08Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42206 | |
dc.description.abstract | Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incidence of myocardial infarction (MI) is complicated by the potentially confounding effects of well-known cardiovascular risk factors. The current study tried to investigate in parallel the association of PAI-1 activity with the PAI-1 4G/5G polymorphism, with MI, and some components of metabolic syndrome (MetS). Methods: Using meta-analytical Mendelian randomization approaches, genotype-disease and genotype-phenotype associations were modeled simultaneously. Results: According to an additive model of inheritance and the Mendelian randomization approach, the MI-related odd ratio for individuals carrying the 4G allele was 1.088 with 95% confidence interval (CI) 1.007, 1.175. Moreover, the 4G carriers had, on average, higher PAI-1 activity than 5G carriers by 1.136 units (95% CI 0.738, 1.533). The metaregression analyses showed that the levels of triglycerides (p =0.005), cholesterol (p=0.037) and PAI-1 (p =0.021) in controls were associated with the MI risk conferred by the 4G carriers. Conclusions: The Mendelian randomization meta-analysis confirmed previous knowledge that the PAI-1 4G allele slightly increases the risk for MI. In addition, it supports the notion that PAI-1 activity and established cardiovascular determinants, such as cholesterol and triglyceride levels, could lie in the etiological pathway from PAI-1 4G allele to the occurrence of MI. Further research is warranted to elucidate these interactions. | en |
dc.language.iso | eng | en |
dc.source | Clinical Chemistry and Laboratory Medicine | en |
dc.subject | Meta-analysis | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Priority journal | en |
dc.subject | Review | en |
dc.subject | Allele | en |
dc.subject | Genetic association | en |
dc.subject | Meta analysis (topic) | en |
dc.subject | Genotype | en |
dc.subject | Heart infarction | en |
dc.subject | Meta analysis | en |
dc.subject | Polymorphism | en |
dc.subject | Genetic | en |
dc.subject | Genetic polymorphism | en |
dc.subject | Risk assessment | en |
dc.subject | Inheritance | en |
dc.subject | Blood | en |
dc.subject | Triacylglycerol | en |
dc.subject | Phenotype | en |
dc.subject | Genetics | en |
dc.subject | Alleles | en |
dc.subject | Cholesterol | en |
dc.subject | 4g/5g polymorphism | en |
dc.subject | Mendelian randomization | en |
dc.subject | Mendelian randomization analysis | en |
dc.subject | Metabolic syndrome x | en |
dc.subject | Myocardial infarction | en |
dc.subject | Plasminogen activator inhibitor 1 | en |
dc.subject | Plasminogen activator inhibitor type 1 (pai-1) | en |
dc.subject | Serpine1 protein | en |
dc.title | The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1515/cclm-2013-1124 | |
dc.description.volume | 52 | |
dc.description.issue | 7 | |
dc.description.startingpage | 937 | |
dc.description.endingpage | 950 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.contributor.orcid | Bonovas, Stefanos [0000-0001-6102-6579] | |
dc.contributor.orcid | Kopterides, Petros [0000-0002-7682-4482] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |
dc.gnosis.orcid | 0000-0001-6102-6579 | |
dc.gnosis.orcid | 0000-0002-7682-4482 | |