Show simple item record

dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorBagos, Pantelis G.en
dc.contributor.authorTsangaris, I.en
dc.contributor.authorTsiara, Chrissa G.en
dc.contributor.authorKopterides, Petrosen
dc.contributor.authorVaiopoulos, A.en
dc.contributor.authorKapsimali, Violettaen
dc.contributor.authorBonovas, Stefanosen
dc.contributor.authorTsantes, Argirio E.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorBagos, Pantelis G.en
dc.creatorTsangaris, I.en
dc.creatorTsiara, Chrissa G.en
dc.creatorKopterides, Petrosen
dc.creatorVaiopoulos, A.en
dc.creatorKapsimali, Violettaen
dc.creatorBonovas, Stefanosen
dc.creatorTsantes, Argirio E.en
dc.date.accessioned2018-06-22T09:54:08Z
dc.date.available2018-06-22T09:54:08Z
dc.date.issued2014
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42206
dc.description.abstractBackground: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incidence of myocardial infarction (MI) is complicated by the potentially confounding effects of well-known cardiovascular risk factors. The current study tried to investigate in parallel the association of PAI-1 activity with the PAI-1 4G/5G polymorphism, with MI, and some components of metabolic syndrome (MetS). Methods: Using meta-analytical Mendelian randomization approaches, genotype-disease and genotype-phenotype associations were modeled simultaneously. Results: According to an additive model of inheritance and the Mendelian randomization approach, the MI-related odd ratio for individuals carrying the 4G allele was 1.088 with 95% confidence interval (CI) 1.007, 1.175. Moreover, the 4G carriers had, on average, higher PAI-1 activity than 5G carriers by 1.136 units (95% CI 0.738, 1.533). The metaregression analyses showed that the levels of triglycerides (p =0.005), cholesterol (p=0.037) and PAI-1 (p =0.021) in controls were associated with the MI risk conferred by the 4G carriers. Conclusions: The Mendelian randomization meta-analysis confirmed previous knowledge that the PAI-1 4G allele slightly increases the risk for MI. In addition, it supports the notion that PAI-1 activity and established cardiovascular determinants, such as cholesterol and triglyceride levels, could lie in the etiological pathway from PAI-1 4G allele to the occurrence of MI. Further research is warranted to elucidate these interactions.en
dc.language.isoengen
dc.sourceClinical Chemistry and Laboratory Medicineen
dc.subjectMeta-analysisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectPriority journalen
dc.subjectReviewen
dc.subjectAlleleen
dc.subjectGenetic associationen
dc.subjectMeta analysis (topic)en
dc.subjectGenotypeen
dc.subjectHeart infarctionen
dc.subjectMeta analysisen
dc.subjectPolymorphismen
dc.subjectGeneticen
dc.subjectGenetic polymorphismen
dc.subjectRisk assessmenten
dc.subjectInheritanceen
dc.subjectBlooden
dc.subjectTriacylglycerolen
dc.subjectPhenotypeen
dc.subjectGeneticsen
dc.subjectAllelesen
dc.subjectCholesterolen
dc.subject4g/5g polymorphismen
dc.subjectMendelian randomizationen
dc.subjectMendelian randomization analysisen
dc.subjectMetabolic syndrome xen
dc.subjectMyocardial infarctionen
dc.subjectPlasminogen activator inhibitor 1en
dc.subjectPlasminogen activator inhibitor type 1 (pai-1)en
dc.subjectSerpine1 proteinen
dc.titleThe association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1515/cclm-2013-1124
dc.description.volume52
dc.description.issue7
dc.description.startingpage937
dc.description.endingpage950
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBagos, Pantelis G. [0000-0003-4935-2325]
dc.contributor.orcidBonovas, Stefanos [0000-0001-6102-6579]
dc.contributor.orcidKopterides, Petros [0000-0002-7682-4482]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0003-4935-2325
dc.gnosis.orcid0000-0001-6102-6579
dc.gnosis.orcid0000-0002-7682-4482


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record