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dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorStanta, G.en
dc.contributor.authorAudisio, R. A.en
dc.creatorPavlidis, Nicholasen
dc.creatorStanta, G.en
dc.creatorAudisio, R. A.en
dc.date.accessioned2018-06-22T09:54:17Z
dc.date.available2018-06-22T09:54:17Z
dc.date.issued2012
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42281
dc.description.abstractLife expectancy has dramatically expanded, the global population has aged unprecedentedly and the number of centenarians has significantly increased. The analysis of autopsy series, cancer registries data, vital statistics and surveys specific to this age group allows unique observations with respect to incidence and prevalence, cause of death by cancer, frequency of primary tumours, metastatic patterns, occurrence of incidental cancers and of multiple primary tumours.Data analysis demonstrates how cancer incidence and cause of death present a threefold decrease after age 90 and reach 0-4% above age 100. In addition, the number of metastatic sites are remarkably less and incidental malignant tumours or multiple primary cancers are more frequent, indicating that cancer in centenarians carries a more indolent behaviour.The unique features of malignant tumours in this population is hereby presented and discussed following a systematic review of the available literature.Cancer in the very elderly is relatively uncommon as a disease and as a cause of death. It is characterized by a slow growth and a modest life-threatening potential. © 2011 Elsevier Ireland Ltd.en
dc.language.isoengen
dc.sourceCritical reviews in oncology/hematologyen
dc.subjectHumanen
dc.subjectNeoplasmsen
dc.subject80 and overen
dc.subjectAgeden
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMortalityen
dc.subjectCancer researchen
dc.subjectReviewen
dc.subjectMetastasisen
dc.subjectCancer mortalityen
dc.subjectSystematic reviewen
dc.subjectMaleen
dc.subjectAge distributionen
dc.subjectRisk assessmenten
dc.subjectSex differenceen
dc.subjectPrevalenceen
dc.subjectCancer incidenceen
dc.subjectCanceren
dc.subjectIncidenceen
dc.subjectCancer localizationen
dc.subjectAgingen
dc.subjectMultiple canceren
dc.subjectVery elderlyen
dc.subjectRegistriesen
dc.subjectPrimary tumoren
dc.subjectHealth surveyen
dc.subjectCancer epidemiologyen
dc.subjectAutopsyen
dc.subjectCancer registryen
dc.subjectCause of deathen
dc.subjectCentenariansen
dc.subjectLife expectancyen
dc.subjectPopulation risken
dc.subjectVital statisticsen
dc.titleCancer prevalence and mortality in centenarians: A systematic reviewen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.critrevonc.2011.09.007
dc.description.volume83
dc.description.issue1
dc.description.startingpage145
dc.description.endingpage152
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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