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dc.contributor.authorStylianou, A.en
dc.contributor.authorStylianopoulos, T.en
dc.creatorStylianou, A.en
dc.creatorStylianopoulos, T.en
dc.date.accessioned2019-05-06T12:24:42Z
dc.date.available2019-05-06T12:24:42Z
dc.date.issued2016
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48875
dc.description.abstractCancer cells have different characteristics from normal cells in terms of morphology, cell–cell interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix interactions. Although the clarification of these characteristics is crucial for the effective development of new therapeutic strategies, they remain poorly identified. Furthermore, tumor microenvironment plays a crucial role in cancer progression and metastasis, and thus, it is of utmost importance to decode and fully understand the crosstalk and the interactions between its different components. Atomic force microscopy (AFM) is an established and multifunctional tool in biomedical sciences with many applications in cancer research. In this review, we discuss the use of AFM in the study of cancer cells and the tumor microenvironment. We first provide a brief overview of AFM operating principles highlighting its contribution to the study of cancer and stromal cells. Next, we present research on the use of AFM in the study of cell-tumor microenvironment interactions during cancer cell migration and invasion. Finally, we discuss the development of coupled AFM modalities and the combination of different kinds of imaging with AFM that have been applied to cancer research. © 2015, Springer Science+Business Media New York.en
dc.language.isoengen
dc.sourceBioNanoScienceen
dc.subjectcancer researchen
dc.subjectArticleen
dc.subjectMetastasisen
dc.subjectcancer cellen
dc.subjectprotein degradationen
dc.subjectcell interactionen
dc.subjectExtracellular matrixen
dc.subjectPathologyen
dc.subjectMechanical propertiesen
dc.subjectCellsen
dc.subjectCytologyen
dc.subjectImagingen
dc.subjectAtomic force microscopyen
dc.subjectTumorsen
dc.subjectBiomechanicsen
dc.subjectDiseasesen
dc.subjectTumor microenvironmenten
dc.subjectYoung modulusen
dc.subjectstroma cellen
dc.subjectNonlinear opticsen
dc.subjectCell cultureen
dc.subjectEnzyme activityen
dc.subjectFibroblastsen
dc.subjectExtracellular matricesen
dc.subjectscanning electron microscopyen
dc.subjectcancer growth factoren
dc.subjectCell migrationen
dc.subjectCoupled AFMen
dc.subjectexosomeen
dc.subjectExtracellular matrix interactionsen
dc.subjectHarmonic generationen
dc.subjectImaging techniquesen
dc.subjectintercellular adhesion molecule 1en
dc.subjectlight related phenomenaen
dc.subjectmatrix attachment region binding proteinen
dc.subjectnerve growth factoren
dc.subjectOperating principlesen
dc.subjectpiezoelectricityen
dc.subjectpodosomeen
dc.subjectprotein kinase Syken
dc.subjectSecond harmonic generationen
dc.subjectStromal cellsen
dc.subjectTherapeutic strategyen
dc.titleAtomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Componentsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s12668-015-0187-4
dc.description.volume6
dc.description.startingpage33
dc.description.endingpage46
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages33-46


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