dc.contributor.author | Constantinou, Constantina | en |
dc.contributor.author | Neophytou, Christiana M. | en |
dc.contributor.author | Vraka, Panayiota S. | en |
dc.contributor.author | Hyatt, John Anthony | en |
dc.contributor.author | Papas, Konstantinos A. | en |
dc.contributor.author | Constantinou, Andreas I. | en |
dc.creator | Constantinou, Constantina | en |
dc.creator | Neophytou, Christiana M. | en |
dc.creator | Vraka, Panayiota S. | en |
dc.creator | Hyatt, John Anthony | en |
dc.creator | Papas, Konstantinos A. | en |
dc.creator | Constantinou, Andreas I. | en |
dc.date.accessioned | 2019-11-04T12:50:24Z | |
dc.date.available | 2019-11-04T12:50:24Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53010 | |
dc.description.abstract | Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and δ-tocotrienol (δ-TT)] and 4 synthetic derivatives [γ- and δ-tocotrienol succinate (γ-TS, δ-TS), α-tocopheryl polyethylene glycol succinate (TPGS), and -tocopheryl polyethylene glycol ether (TPGS-e)] of vitamin E to induce cell death in AR (DU145 and PC-3) and AR+ (LNCaP) prostate cancer cell lines. Our results show that δ-TT and TPGS-e are the most effective isoform and synthetic derivative, respectively, of all compounds examined. Overall, the results of our study suggest that isoforms and synthetic derivatives of vitamin E have the potency to trigger both caspase-dependent and -independent DNA damage and dominant caspase-independent programmed cell death. The capacity of vitamin E to trigger caspase-independent programmed cell death suggests that it may be useful in the chemotherapy of prostate cancer since it may prevent the tumor resistance commonly associated with the use of classical chemotherapeutic agents that trigger caspase-dependent programmed cell death. © 2012 Copyright Taylor and Francis Group, LLC. | en |
dc.source | Nutrition and cancer | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856845784&doi=10.1080%2f01635581.2012.630167&partnerID=40&md5=cec01e4681feb77cec88a4e52b025b87 | |
dc.subject | article | en |
dc.subject | Male | en |
dc.subject | antineoplastic agent | en |
dc.subject | etoposide | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | unclassified drug | en |
dc.subject | prostate cancer | en |
dc.subject | Polyethylene Glycols | en |
dc.subject | human cell | en |
dc.subject | apoptosis | en |
dc.subject | enzyme activity | en |
dc.subject | Prostatic Neoplasms | en |
dc.subject | cancer cell culture | en |
dc.subject | Caspases | en |
dc.subject | DNA damage | en |
dc.subject | caspase 3 | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Drug Screening Assays, Antitumor | en |
dc.subject | alpha tocopherol | en |
dc.subject | Vitamin E | en |
dc.subject | alpha tocopheryl polyethylene glycol ether | en |
dc.subject | alpha tocopheryl polyethylene glycol succinate | en |
dc.subject | carbobenzoxy valylalanylaspartyl(o methyl)fluoromethyl ketone | en |
dc.subject | caspase inhibitor | en |
dc.subject | delta tocotrienol | en |
dc.subject | delta tocotrienol succinate | en |
dc.subject | gamma tocotrienol | en |
dc.subject | gamma tocotrienol succinate | en |
dc.subject | Isomerism | en |
dc.subject | Poly(ADP-ribose) Polymerases | en |
dc.title | Induction of DNA damage and caspase-independent programmed cell death by vitamin e | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1080/01635581.2012.630167 | |
dc.description.volume | 64 | |
dc.description.startingpage | 136 | |
dc.description.endingpage | 152 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :18</p> | en |
dc.source.abbreviation | Nutr.Cancer | en |
dc.contributor.orcid | Constantinou, Andreas I. [0000-0003-0365-1821] | |
dc.gnosis.orcid | 0000-0003-0365-1821 | |