dc.contributor.author | Demetriou, Victoria L. | en |
dc.contributor.author | Van De Vijver, D. A. M. C. | en |
dc.contributor.author | Hezka, Johana | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.contributor.author | Savvopoulou, Natasa | en |
dc.contributor.author | Georgiades, Neoklis | en |
dc.contributor.author | Charilaou, Charis C. | en |
dc.contributor.author | Argyriou, Argyris | en |
dc.contributor.author | Pavlou, Tina | en |
dc.contributor.author | Platritis, Kyriakos | en |
dc.contributor.author | Veresies, Kyriakos L. | en |
dc.creator | Demetriou, Victoria L. | en |
dc.creator | Van De Vijver, D. A. M. C. | en |
dc.creator | Hezka, Johana | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.creator | Savvopoulou, Natasa | en |
dc.creator | Georgiades, Neoklis | en |
dc.creator | Charilaou, Charis C. | en |
dc.creator | Argyriou, Argyris | en |
dc.creator | Pavlou, Tina | en |
dc.creator | Platritis, Kyriakos | en |
dc.creator | Veresies, Kyriakos L. | en |
dc.date.accessioned | 2019-11-04T12:50:30Z | |
dc.date.available | 2019-11-04T12:50:30Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53049 | |
dc.description.abstract | The most high-risk population for HCV transmission worldwide today are intravenous drug users. HCV genotypes in the general population in Cyprus demonstrate a polyphyletic infection and include subtypes associated with intravenous drug users. The prevalence of HCV, HBV, and HIV infection, HCV genotypes and risk factors among intravenous drug users in Cyprus were investigated here for the first time. Blood samples and interviews were obtained from 40 consenting users in treatment centers, and were tested for HCV, HBV, and HIV antibodies. On the HCV-positive samples, viral RNA extraction, RT-PCR and sequencing were performed. Phylogenetic analysis determined subtype and any relationships with database sequences and statistical analysis determined any correlation of risk factors with HCV infection. The prevalence of HCV infection was 50%, but no HBV or HIV infections were found. Of the PCR-positive samples, eight (57%) were genotype 3a, and six (43%)were 1b.Noother subtypes, recombinant strainsormixed infections were observed. The phylogenetic analysis of the injecting drug users' strains against database sequences observed no clustering, which does not allow determination of transmission route, possibly due to a limitation of sequences in the database. However, three clusters were discovered among the drug users' sequences, revealing small groups who possibly share injecting equipment. Statistical analysis showed the risk factor associated with HCV infection is drug use duration. Overall, the polyphyletic nature of HCV infection in Cyprus is confirmed, but the transmission route remains unknown. These findings highlight the need for harm-reduction strategies to reduce HCV transmission. © 2009 Wiley-Liss, Inc. | en |
dc.source | Journal of medical virology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-74549193866&doi=10.1002%2fjmv.21690&partnerID=40&md5=8f7ef1789a46c8e399440195af840be0 | |
dc.subject | Cyprus | en |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | adult | en |
dc.subject | female | en |
dc.subject | clinical article | en |
dc.subject | Human immunodeficiency virus infection | en |
dc.subject | male | en |
dc.subject | genotype | en |
dc.subject | Risk Factors | en |
dc.subject | HIV Infections | en |
dc.subject | intravenous drug abuse | en |
dc.subject | virus strain | en |
dc.subject | hepatitis C | en |
dc.subject | prevalence | en |
dc.subject | blood sampling | en |
dc.subject | infection risk | en |
dc.subject | Human immunodeficiency virus antibody | en |
dc.subject | Hepacivirus | en |
dc.subject | Hepatitis C virus | en |
dc.subject | virus RNA | en |
dc.subject | gene sequence | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | reverse transcription polymerase chain reaction | en |
dc.subject | phylogeny | en |
dc.subject | Drug Users | en |
dc.subject | Cluster Analysis | en |
dc.subject | hepatitis B | en |
dc.subject | Hepatitis B virus | en |
dc.subject | hepatitis B antibody | en |
dc.subject | nucleotide sequence | en |
dc.subject | HIV Antibodies | en |
dc.subject | Molecular epidemiology | en |
dc.subject | Phylogenetic analysis | en |
dc.subject | gene cluster | en |
dc.subject | RNA extraction | en |
dc.subject | Hepatitis B Antibodies | en |
dc.subject | Sequence Analysis, DNA | en |
dc.subject | Sequence Homology | en |
dc.subject | RNA, Viral | en |
dc.subject | Core-E1 region | en |
dc.subject | glycoprotein E1 | en |
dc.subject | HCV genotypes | en |
dc.subject | Hepatitis C Antibodies | en |
dc.subject | hepatitis C antibody | en |
dc.subject | interview | en |
dc.subject | nonstructural protein 5B | en |
dc.subject | NS5B region | en |
dc.subject | rehabilitation center | en |
dc.subject | sequence database | en |
dc.subject | Substance Abuse, Intravenous | en |
dc.subject | transactivation | en |
dc.title | Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/jmv.21690 | |
dc.description.volume | 82 | |
dc.description.startingpage | 263 | |
dc.description.endingpage | 270 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :22</p> | en |
dc.source.abbreviation | J.Med.Virol. | en |
dc.contributor.orcid | Kostrikis, Leontios G. [0000-0002-5340-7109] | |
dc.gnosis.orcid | 0000-0002-5340-7109 | |