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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis

dc.contributor.authorGerhäuser, C.en
dc.contributor.authorMar, W.en
dc.contributor.authorLee, S. K.en
dc.contributor.authorSuh, N.en
dc.contributor.authorLuo, Y.en
dc.contributor.authorKosmeder, J.en
dc.contributor.authorLuyengi, L.en
dc.contributor.authorFong, H. H. S.en
dc.contributor.authorKinghorn, A. D.en
dc.contributor.authorMoriarty, R. M.en
dc.contributor.authorMehta, R. G.en
dc.contributor.authorConstantinou, Andreas I.en
dc.contributor.authorMoon, R. C.en
dc.contributor.authorPezzuto, J. M.en
dc.creatorGerhäuser, C.en
dc.creatorMar, W.en
dc.creatorLee, S. K.en
dc.creatorSuh, N.en
dc.creatorLuo, Y.en
dc.creatorKosmeder, J.en
dc.creatorLuyengi, L.en
dc.creatorFong, H. H. S.en
dc.creatorKinghorn, A. D.en
dc.creatorMoriarty, R. M.en
dc.creatorMehta, R. G.en
dc.creatorConstantinou, Andreas I.en
dc.creatorMoon, R. C.en
dc.creatorPezzuto, J. M.en
dc.date.accessioned2019-11-04T12:50:38Z
dc.date.available2019-11-04T12:50:38Z
dc.date.issued1995
dc.identifier.issn1078-8956
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53104
dc.description.abstractFor the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were obtained from the African plant Mundulea sericea (Leguminosae). These isolates were highly potent when evaluated for inhibition of chemically induced preneoplastic lesions in mammary organ culture and inhibition of papillomas in the two-stage mouse skin model, and they appear to function by a unique mechanism at the level of ODC messenger RNA expression. Based on our findings, rotenoids can be regarded as promising new chemopreventive or anticancer agents. © 1995 Nature Publishing Group.en
dc.sourceNature medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0028962404&doi=10.1038%2fnm0395-260&partnerID=40&md5=6c6161565d3b5d5bb002f4718fcdb98e
dc.subjectarticleen
dc.subjectFemaleen
dc.subjectantineoplastic agenten
dc.subjectbreast canceren
dc.subjectcontrolled studyen
dc.subjectpriority journalen
dc.subjectretinoic aciden
dc.subjectSkin Neoplasmsen
dc.subjectHumanen
dc.subjectunclassified drugen
dc.subjectcarcinogenesisen
dc.subjectcancer preventionen
dc.subjectnonhumanen
dc.subjectdrug mechanismen
dc.subjectMiceen
dc.subjectAnimalen
dc.subjectanimal experimenten
dc.subjectanimal tissueen
dc.subjectmouseen
dc.subjecttranscription regulationen
dc.subjectCell Differentiationen
dc.subjectcancer inhibitionen
dc.subjectSupport, Non-U.S. Gov'ten
dc.subjectcell cultureen
dc.subjectHL-60 Cellsen
dc.subjectSupport, U.S. Gov't, P.H.S.en
dc.subjectGene Expression Regulation, Enzymologicen
dc.subjectRNA, Messengeren
dc.subjectProtein Kinase Cen
dc.subjectTetradecanoylphorbol Acetateen
dc.subjectMice, Inbred BALB Cen
dc.subject9,10-Dimethyl-1,2-benzanthraceneen
dc.subjectAntineoplastic Agents, Phytogenicen
dc.subjectCells, Cultureden
dc.subjectdeguelinen
dc.subjectlegumeen
dc.subjectNeoplasms, Experimentalen
dc.subjectOrgan Cultureen
dc.subjectornithine decarboxylaseen
dc.subjectprecanceren
dc.subjectPrecancerous Conditionsen
dc.subjectRotenoneen
dc.subjecttephrosinen
dc.titleRotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/nm0395-260
dc.description.volume1
dc.description.startingpage260
dc.description.endingpage266
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :97</p>en
dc.source.abbreviationNat.Med.en
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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