dc.contributor.author | Hassapis, K. A. | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.creator | Hassapis, K. A. | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.date.accessioned | 2019-11-04T12:50:41Z | |
dc.date.available | 2019-11-04T12:50:41Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1570-162X | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53123 | |
dc.description.abstract | Antigen-presenting viral vectors have been extensively used as vehicles for the presentation of antigens to the immune system in numerous vaccine strategies. Particularly in HIV vaccine development efforts, two main viral vectors have been used as antigen carriers: (a) live attenuated vectors and (b) virus-like particles (VLPs) | en |
dc.description.abstract | the former, although highly effective in animal studies, cannot be clinically tested in humans due to safety concerns and the latter have failed to induce broadly neutralizing anti-HIV antibodies. For more than two decades, Inoviruses (non-lytic bacterial phages) have also been utilized as antigen carriers in several vaccine studies. Inoviral vectors are important antigen-carriers in vaccine development due to their ability to present an antigen on their outer architecture in many copies and to their natural high immunogenicity. Numerous fundamental studies have been conducted, which have established the unique properties of antigen-displayed inoviral vectors in HIV vaccine efforts. The recent isolation of new, potent anti-HIV broadly neutralizing monoclonal antibodies provides a new momentum in this emerging technology. © 2013 Bentham Science Publishers. | en |
dc.source | Current HIV Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84900480020&doi=10.2174%2f1570162X12666140209135651&partnerID=40&md5=e13cbc930a1132b4bb4ecde9ccd34646 | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | gene product | en |
dc.subject | HIV Infections | en |
dc.subject | nonhuman | en |
dc.subject | immune response | en |
dc.subject | immunology | en |
dc.subject | genetics | en |
dc.subject | Human immunodeficiency virus antibody | en |
dc.subject | gene mutation | en |
dc.subject | Human immunodeficiency virus 1 | en |
dc.subject | HIV-1 | en |
dc.subject | Gag protein | en |
dc.subject | DNA sequence | en |
dc.subject | vaccination | en |
dc.subject | crystal structure | en |
dc.subject | Genetic Vectors | en |
dc.subject | virus vector | en |
dc.subject | Human immunodeficiency virus vaccine | en |
dc.subject | bacteriophage | en |
dc.subject | gene vector | en |
dc.subject | AIDS Vaccines | en |
dc.subject | Antigen-display | en |
dc.subject | Bacteriophages | en |
dc.subject | epitope mapping | en |
dc.subject | glycoprotein gp 120 | en |
dc.subject | glycoprotein gp 41 | en |
dc.subject | HIV Antigens | en |
dc.subject | HIV neutralizing antibodies | en |
dc.subject | HIV vaccine | en |
dc.subject | Human immunodeficiency virus antigen | en |
dc.subject | immunogenicity | en |
dc.subject | Inoviridae | en |
dc.subject | Inovirus-display | en |
dc.subject | peptide library | en |
dc.subject | Phage-display | en |
dc.subject | scanning transmission electron microscopy | en |
dc.subject | Viral vectors | en |
dc.subject | virus like particle vaccine | en |
dc.title | HIV-1 vaccine strategies utilizing viral vectors including antigen-displayed inoviral vectors | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.2174/1570162X12666140209135651 | |
dc.description.volume | 11 | |
dc.description.startingpage | 610 | |
dc.description.endingpage | 622 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :1</p> | en |
dc.source.abbreviation | Curr.HIV Res. | en |
dc.contributor.orcid | Kostrikis, Leontios G. [0000-0002-5340-7109] | |
dc.gnosis.orcid | 0000-0002-5340-7109 | |