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dc.contributor.authorJacomin, A. -Cen
dc.contributor.authorSamavedam, S.en
dc.contributor.authorPromponas, Vasilis J.en
dc.contributor.authorNezis, I. P.en
dc.creatorJacomin, A. -Cen
dc.creatorSamavedam, S.en
dc.creatorPromponas, Vasilis J.en
dc.creatorNezis, I. P.en
dc.date.accessioned2019-11-04T12:51:45Z
dc.date.available2019-11-04T12:51:45Z
dc.date.issued2016
dc.identifier.issn1554-8627
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53142
dc.description.abstractAtg8-family proteins are the best-studied proteins of the core autophagic machinery. They are essential for the elongation and closure of the phagophore into a proper autophagosome. Moreover, Atg8-family proteins are associated with the phagophore from the initiation of the autophagic process to, or just prior to, the fusion between autophagosomes with lysosomes. In addition to their implication in autophagosome biogenesis, they are crucial for selective autophagy through their ability to interact with selective autophagy receptor proteins necessary for the specific targeting of substrates for autophagic degradation. In the past few years it has been revealed that Atg8-interacting proteins include not only receptors but also components of the core autophagic machinery, proteins associated with vesicles and their transport, and specific proteins that are selectively degraded by autophagy. Atg8-interacting proteins contain a short linear LC3-interacting region/LC3 recognition sequence/Atg8-interacting motif (LIR/LRS/AIM) motif which is responsible for their interaction with Atg8-family proteins. These proteins are referred to as LIR-containing proteins (LIRCPs). So far, many experimental efforts have been carried out to identify new LIRCPs, leading to the characterization of some of them in the past 10 years. Given the need for the identification of LIRCPs in various organisms, we developed the iLIR database (https://ilir.warwick.ac.uk) as a freely available web resource, listing all the putative canonical LIRCPs identified in silico in the proteomes of 8 model organisms using the iLIR server, combined with a Gene Ontology (GO) term analysis. Additionally, a curated text-mining analysis of the literature permitted us to identify novel putative LICRPs in mammals that have not previously been associated with autophagy. © 2016 The Author(s). Published with license by Taylor & Francis. © Anne-Claire Jacomin, Siva Samavedam, Vasilis Promponas, and Ioannis P. Nezis.en
dc.sourceAutophagyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84982282667&doi=10.1080%2f15548627.2016.1207016&partnerID=40&md5=dc16a41f7487d87a67abc1a9f51cb29c
dc.subjecthumanen
dc.subjectcontrolled studyen
dc.subjectpredictionen
dc.subjectamino acid sequenceen
dc.subjectprotein analysisen
dc.subjectunclassified drugen
dc.subjectnonhumanen
dc.subjectArticleen
dc.subjectanimal experimenten
dc.subjectmouseen
dc.subjectprotein motifen
dc.subjectcomputer modelen
dc.subjectprotein protein interactionen
dc.subjecteukaryoteen
dc.subjectproteomeen
dc.subjectSaccharomyces cerevisiaeen
dc.subjectraten
dc.subjectMus musculusen
dc.subjectAIMen
dc.subjectArabidopsis thalianaen
dc.subjectATG8en
dc.subjectatg8 proteinen
dc.subjectCaenorhabditis elegansen
dc.subjectcell membrane proteinen
dc.subjectcell proteinen
dc.subjectdata miningen
dc.subjectdatabaseen
dc.subjectGallus gallusen
dc.subjectgene ontologyen
dc.subjectiLIR databaseen
dc.subjectLC3-interacting region motifen
dc.subjectlight chain 3 proteinen
dc.subjectLIRen
dc.subjectLIR containing proteinen
dc.subjectLIR-containing proteinen
dc.subjectLIRCPen
dc.subjectLRSen
dc.subjectmyosin light chainen
dc.subjectprotein databaseen
dc.subjectRattus norvegicusen
dc.subjectreceptor proteinen
dc.subjectselective autophagyen
dc.subjectzebra fishen
dc.titleiLIR database: A web resource for LIR motif-containing proteins in eukaryotesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1080/15548627.2016.1207016
dc.description.volume12
dc.description.startingpage1945
dc.description.endingpage1953
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :3</p>en
dc.source.abbreviationAutophagyen
dc.contributor.orcidPromponas, Vasilis J. [0000-0003-3352-4831]
dc.gnosis.orcid0000-0003-3352-4831


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