Show simple item record

Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques

dc.contributor.authorJin, X.en
dc.contributor.authorBauer, D. E.en
dc.contributor.authorTuttleton, S. E.en
dc.contributor.authorLewin, S.en
dc.contributor.authorGettie, A.en
dc.contributor.authorBlanchard, J.en
dc.contributor.authorIrwin, C. E.en
dc.contributor.authorSafrit, J. T.en
dc.contributor.authorMittler, J.en
dc.contributor.authorWeinberger, L.en
dc.contributor.authorKostrikis, Leontios G.en
dc.contributor.authorZhang, L.en
dc.contributor.authorPerelson, A. S.en
dc.contributor.authorHo, David D.en
dc.creatorJin, X.en
dc.creatorBauer, D. E.en
dc.creatorTuttleton, S. E.en
dc.creatorLewin, S.en
dc.creatorGettie, A.en
dc.creatorBlanchard, J.en
dc.creatorIrwin, C. E.en
dc.creatorSafrit, J. T.en
dc.creatorMittler, J.en
dc.creatorWeinberger, L.en
dc.creatorKostrikis, Leontios G.en
dc.creatorZhang, L.en
dc.creatorPerelson, A. S.en
dc.creatorHo, David D.en
dc.date.accessioned2019-11-04T12:51:46Z
dc.date.available2019-11-04T12:51:46Z
dc.date.issued1999
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53143
dc.description.abstractTo determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was on average a 99.9% reduction of CD8 cells in peripheral blood in six infected Macaca mulatta treated with OKT8F. The apparent CD8 depletion started 1 h after antibody administration, and low CD8 levels were maintained until day 8. An increase in plasma viremia of one to three orders of magnitude was observed in five of the six macaques. The injection of a control antibody to an infected macaque did not induce a sustained viral load increase, nor did it significantly reduce the number of CD8+ T cells. These results demonstrate that CD8 cells play a crucial role in suppressing SIV replication in vivo.en
dc.sourceJournal of Experimental Medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0033559648&doi=10.1084%2fjem.189.6.991&partnerID=40&md5=33eed2f453d4d286900fb2843651886c
dc.subjectarticleen
dc.subjectcontrolled studyen
dc.subjectpriority journalen
dc.subjectcellular immunityen
dc.subjectnonhumanen
dc.subjectCD4-Positive T-Lymphocytesen
dc.subjectAnimalsen
dc.subjectanimal cellen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectCD8-Positive T-Lymphocytesen
dc.subjectvirus loaden
dc.subjectvirus replicationen
dc.subjectSimian immunodeficiency virusen
dc.subjectCytotoxic T lymphocyteen
dc.subjectmacacaen
dc.subjectMacaca mulattaen
dc.subjectMacaqueen
dc.subjectOKT8en
dc.subjectretrovirus infectionen
dc.subjectSimian Acquired Immunodeficiency Syndromeen
dc.subjectViremiaen
dc.subjectvirus inhibitionen
dc.titleDramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaquesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1084/jem.189.6.991
dc.description.volume189
dc.description.startingpage991
dc.description.endingpage998
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :1106</p>en
dc.source.abbreviationJ.Exp.Med.en
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]
dc.gnosis.orcid0000-0002-5340-7109


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record