The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies
dc.contributor.author | Kapsetaki, Stefania Elisavet | en |
dc.contributor.author | Tzelepis, Ilias | en |
dc.contributor.author | Avgousti, Kalodoti | en |
dc.contributor.author | Livadaras, Ioannis | en |
dc.contributor.author | Garantonakis, Nikos G. | en |
dc.contributor.author | Varikou, Kyriaki N. | en |
dc.contributor.author | Apidianakis, Yiorgos | en |
dc.creator | Kapsetaki, Stefania Elisavet | en |
dc.creator | Tzelepis, Ilias | en |
dc.creator | Avgousti, Kalodoti | en |
dc.creator | Livadaras, Ioannis | en |
dc.creator | Garantonakis, Nikos G. | en |
dc.creator | Varikou, Kyriaki N. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.date.accessioned | 2019-11-04T12:51:47Z | |
dc.date.available | 2019-11-04T12:51:47Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53151 | |
dc.description.abstract | Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the 'grape-like' odorant 2-aminoacetophenone (2AA), secreted by Pseudomonas aeruginosa (a ubiquitous opportunistic human pathogen), facilitates attraction to food for several fly species including Musca domestica, Ceratitis capitata and Drosophila melanogaster. Constant feeding on 2AA increases the level of long-term colonization of the flies' intestine by P. aeruginosa. Odour perception is necessary for enhanced attraction to food containing 2AA, and expression in the Drosophila olfactory organs of odorant receptors Or49b and Or10a potentiates, while expression of Or85a inhibits, preference for 2AA. Our study shows that 2AA lures the flies to the bacterial source and increases the extent of colonization of the fly intestine by the bacteria that produce it, as a means to facilitate bacterial dissemination to new locations. © 2014 Macmillan Publishers Limited. | en |
dc.source | Nature Communications | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904626049&doi=10.1038%2fncomms5401&partnerID=40&md5=56fa8bcdd4456e52ffbf0f88bf96754f | |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | unclassified drug | en |
dc.subject | nonhuman | en |
dc.subject | metabolism | en |
dc.subject | gene expression | en |
dc.subject | Animals | en |
dc.subject | animal | en |
dc.subject | bacterial load | en |
dc.subject | genetics | en |
dc.subject | microbiology | en |
dc.subject | physiology | en |
dc.subject | pathogenicity | en |
dc.subject | drug effects | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | Intestines | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | Animals, Genetically Modified | en |
dc.subject | Drosophila Proteins | en |
dc.subject | fly | en |
dc.subject | Drosophila protein | en |
dc.subject | transgenic animal | en |
dc.subject | intestine | en |
dc.subject | metabolite | en |
dc.subject | food | en |
dc.subject | Behavior, Animal | en |
dc.subject | Diptera | en |
dc.subject | 2 aminoacetophenone | en |
dc.subject | 2-aminoacetophenone | en |
dc.subject | acetophenone derivative | en |
dc.subject | Acetophenones | en |
dc.subject | animal behavior | en |
dc.subject | bacterial colonization | en |
dc.subject | Ceratitis capitata | en |
dc.subject | colonization | en |
dc.subject | feeding | en |
dc.subject | house fly | en |
dc.subject | Houseflies | en |
dc.subject | Mediterranean fruit fly | en |
dc.subject | microbial activity | en |
dc.subject | odor | en |
dc.subject | Odors | en |
dc.subject | olfactory receptor | en |
dc.subject | olfactory system | en |
dc.subject | pathogen | en |
dc.subject | receptor | en |
dc.subject | receptor Or10a | en |
dc.subject | receptor Or49b | en |
dc.subject | receptor Or85a | en |
dc.subject | Receptors, Odorant | en |
dc.title | The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/ncomms5401 | |
dc.description.volume | 5 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :2</p> | en |
dc.source.abbreviation | Nat.Commun. | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 |
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