Global distribution of the CCR2-641/CCR5-59653T HIV-1 disease-protective haplotype
dc.contributor.author | Martinson, J. J. | en |
dc.contributor.author | Hong, L. | en |
dc.contributor.author | Karanicolas, R. | en |
dc.contributor.author | Moore, J. P. | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.creator | Martinson, J. J. | en |
dc.creator | Hong, L. | en |
dc.creator | Karanicolas, R. | en |
dc.creator | Moore, J. P. | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.date.accessioned | 2019-11-04T12:52:20Z | |
dc.date.available | 2019-11-04T12:52:20Z | |
dc.date.issued | 2000 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53242 | |
dc.description.abstract | Objectives: Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. The CCR2-641 genetic variant [a G to A substitution resulting in a valine (V) to isoleucine (I) change at position 64] is in strong linkage disequilibrium with a mutation within the CCR5 regulatory region (CCR5-59653T). Individuals with two CCR2-641 alleles are not resistant to sexual transmission of HIV-1, but progress significantly more slowly to HIV-1 disease. It is therefore important to determine the global distributions of CCR2-641 and CCR5-59653T genetic variants and define the degree of linkage between them. Design and methods: We have developed molecular beacon-based, real-time PCR allele discrimination assays for all three chemokine receptor mutations, and used these spectral genotyping assays to genotype 3923 individuals from a globally distributed set of 53 populations. Results: CCR2-641 and CCR5-59653T genetic variants are found in almost all populations studied: their allele frequencies are greatest (~35%) in Africa and Asia but decrease in Northern Europe. We confirm that CCR2-641 is in strong linkage disequilibrium with CCR5-59653T (96.92% of individuals had the same genotype for both CCR2-641 and CCR5-59653T polymorphisms). Conclusions: The greater geographical distribution of the CCR2-641/CCR5-59653T haplotype compared with that of CCR5-Δ32 suggests that it is a much older mutation whose origin predates the dispersal of modern humans. (C) 2000 Lippincott Williams and Wilkins. | en |
dc.source | AIDS | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034119188&doi=10.1097%2f00002030-200003310-00003&partnerID=40&md5=20e0d16e885f024c62de4760fc6023e8 | |
dc.subject | Europe | en |
dc.subject | Asia | en |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | priority journal | en |
dc.subject | DNA polymorphism | en |
dc.subject | gene frequency | en |
dc.subject | genotype | en |
dc.subject | unclassified drug | en |
dc.subject | HIV Infections | en |
dc.subject | World Health | en |
dc.subject | Alleles | en |
dc.subject | Mutation | en |
dc.subject | polymerase chain reaction | en |
dc.subject | receptor gene | en |
dc.subject | HIV | en |
dc.subject | Polymorphisms | en |
dc.subject | Human immunodeficiency virus 1 | en |
dc.subject | HIV-1 | en |
dc.subject | Africa | en |
dc.subject | CCR5 | en |
dc.subject | normal human | en |
dc.subject | chemokine receptor | en |
dc.subject | Receptors, Chemokine | en |
dc.subject | haplotype | en |
dc.subject | Haplotypes | en |
dc.subject | infection resistance | en |
dc.subject | chemokine receptor CCR5 | en |
dc.subject | Receptors, CCR5 | en |
dc.subject | genetic linkage | en |
dc.subject | CCR2 | en |
dc.subject | chemokine receptor ccr2 | en |
dc.subject | Co-receptors | en |
dc.subject | Genetic Screening | en |
dc.title | Global distribution of the CCR2-641/CCR5-59653T HIV-1 disease-protective haplotype | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1097/00002030-200003310-00003 | |
dc.description.volume | 14 | |
dc.description.startingpage | 483 | |
dc.description.endingpage | 489 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :62</p> | en |
dc.source.abbreviation | AIDS | en |
dc.contributor.orcid | Kostrikis, Leontios G. [0000-0002-5340-7109] | |
dc.gnosis.orcid | 0000-0002-5340-7109 |
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