Outcome of kidney transplantation in autosomal dominant medullary cystic kidney disease type 1
dc.contributor.author | Stavrou, Christoforos V. | en |
dc.contributor.author | Constantinou-Deltas, Constantinos D. | en |
dc.contributor.author | Christofides, Tasos C. | en |
dc.contributor.author | Pierides, Alkis M. | en |
dc.creator | Stavrou, Christoforos V. | en |
dc.creator | Constantinou-Deltas, Constantinos D. | en |
dc.creator | Christofides, Tasos C. | en |
dc.creator | Pierides, Alkis M. | en |
dc.date.accessioned | 2019-11-04T12:52:44Z | |
dc.date.available | 2019-11-04T12:52:44Z | |
dc.date.issued | 2003 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53402 | |
dc.description.abstract | Background. Autosomal dominant medullary cystic kidney disease (ADMCKD) is an inherited, distinct, chronic, tubulointerstitial, cystic-type nephropathy, often described together with juvenile nephronophthisis as a single disease complex (NPH-MCD). However, since the recent localization of two genes responsible for ADMCKD, namely MCKD1 and MCKD2, ADMCKD has gained independent status. Unfortunately, there appears to be a distinct lack of up-to-date information in the currently available medical literature concerning worldwide patient and graft survival after renal transplantation in ADMCKD. This report is based on all 41 transplanted patients [19 suffering from autosomal dominant medullary cystic kidney disease type 1 (ADMCKD1) and 22 from other causes] who were referred for kidney transplantation from our centre in Pafos, Cyprus between 1976 and 2000. All patients had regular follow-up examinations. This report aims to present the results of kidney transplantation of the 19 ADMCKD1 patients and to compare them with those for the 22 non-ADMCKD patients. Methods. Patient and graft survival times in both groups were recorded, analysed and compared 1 and 5 years post-transplant. Patient and graft survival times were calculated according to the Kaplan-Meier method and some descriptive statistical comparisons were based on the χ2-test. Results. The 1 year patient and graft survival rates for ADMCKD1 (group A) were 100%, while the 5 year figures were 100% and 90%, respectively. For non-ADMCKD1 patients (group B) the 1 year figures were 95% for both parameters, while the 5 year figures were 93.3% for both parameters. There were no statistically significant differences in patient and graft survival times between the two groups. Conclusions. Kidney transplantation is the treatment of choice for patients suffering from ADMCKD, with an excellent outcome and no specific complications. | en |
dc.source | Nephrology Dialysis Transplantation | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0141506997&doi=10.1093%2fndt%2fgfg196&partnerID=40&md5=42c82e5137a7011c390c1c0c7c38fce0 | |
dc.subject | Cyprus | en |
dc.subject | Age Factors | en |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | adult | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | Middle Aged | en |
dc.subject | follow up | en |
dc.subject | priority journal | en |
dc.subject | Retrospective Studies | en |
dc.subject | clinical article | en |
dc.subject | Survival Analysis | en |
dc.subject | treatment outcome | en |
dc.subject | male | en |
dc.subject | intermethod comparison | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Risk Assessment | en |
dc.subject | Sex Factors | en |
dc.subject | Kaplan Meier method | en |
dc.subject | kidney failure | en |
dc.subject | disease classification | en |
dc.subject | postoperative complication | en |
dc.subject | Sampling Studies | en |
dc.subject | Cause of Death | en |
dc.subject | Tissue Donors | en |
dc.subject | medullary sponge kidney | en |
dc.subject | Polycystic Kidney, Autosomal Dominant | en |
dc.subject | autosomal dominant disorder | en |
dc.subject | Autosomal dominant medullary cystic kidney disease | en |
dc.subject | Kidney transplantation | en |
dc.subject | Nephronophthisis | en |
dc.subject | cadaver donor | en |
dc.subject | Graft Rejection | en |
dc.subject | graft survival | en |
dc.subject | kidney donor | en |
dc.subject | kidney graft rejection | en |
dc.subject | living donor | en |
dc.subject | renal system parameters | en |
dc.title | Outcome of kidney transplantation in autosomal dominant medullary cystic kidney disease type 1 | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1093/ndt/gfg196 | |
dc.description.volume | 18 | |
dc.description.startingpage | 2165 | |
dc.description.endingpage | 2169 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :10</p> | en |
dc.source.abbreviation | Nephrol.Dial.Transplant. | en |
dc.contributor.orcid | Christofides, Tasos C. [0000-0001-6121-0683] | |
dc.contributor.orcid | Constantinou-Deltas, Constantinos D. [0000-0001-5549-9169] | |
dc.gnosis.orcid | 0000-0001-6121-0683|0000-0001-5549-9169 |
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