dc.contributor.author | Valentin, A. | en |
dc.contributor.author | Rosati, M. | en |
dc.contributor.author | Patenaude, D. J. | en |
dc.contributor.author | Hatzakis, Angelos E. | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.contributor.author | Lazanas, Marios C. | en |
dc.contributor.author | Wyvill, K. M. | en |
dc.contributor.author | Yarchoan, R. | en |
dc.contributor.author | Pavlakis, G. N. | en |
dc.creator | Valentin, A. | en |
dc.creator | Rosati, M. | en |
dc.creator | Patenaude, D. J. | en |
dc.creator | Hatzakis, Angelos E. | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.creator | Lazanas, Marios C. | en |
dc.creator | Wyvill, K. M. | en |
dc.creator | Yarchoan, R. | en |
dc.creator | Pavlakis, G. N. | en |
dc.date.accessioned | 2019-11-04T12:52:47Z | |
dc.date.available | 2019-11-04T12:52:47Z | |
dc.date.issued | 2002 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53426 | |
dc.description.abstract | We have identified a subset of CD56+CD3- human natural killer (NK) cells that express CD4 and the HIV coreceptors CCR5 and CXCR4. These cells can be productively infected in vitro by both CCR5- and CXCR4-using molecular clones of HIV-1 in a CD4-dependent manner. Analysis of HIV-infected persons showed that viral DNA is present in purified NK cells, and virus could be rescued from these cells after in vitro cultivation. Longitudinal analysis of the HIV-1 DNA levels in NK cells from patients after 1-2 years of highly active antiretroviral therapy indicated that NK cells remain persistently infected and account for a substantial amount of the viral DNA in peripheral blood mononuclear cells. These results demonstrate that a subset of non-T cells with NK markers are persistently infected and suggest that HIV infection of NK cells is important for virus persistence. The properties of the virus reservoir in these cells should be considered in attempts to further optimize antiretroviral therapies. | en |
dc.source | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037076343&doi=10.1073%2fpnas.102672999&partnerID=40&md5=99f176b60339fa46ebabad7aa274382e | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | priority journal | en |
dc.subject | Human immunodeficiency virus infection | en |
dc.subject | HIV Infections | en |
dc.subject | Human immunodeficiency virus | en |
dc.subject | human cell | en |
dc.subject | CD4-Positive T-Lymphocytes | en |
dc.subject | flow cytometry | en |
dc.subject | natural killer cell | en |
dc.subject | T lymphocyte activation | en |
dc.subject | virus load | en |
dc.subject | mononuclear cell | en |
dc.subject | Anti-HIV Agents | en |
dc.subject | Human immunodeficiency virus 1 | en |
dc.subject | HIV-1 | en |
dc.subject | antiretrovirus agent | en |
dc.subject | virus replication | en |
dc.subject | longitudinal study | en |
dc.subject | chemokine receptor CXCR4 | en |
dc.subject | chemokine receptor CCR5 | en |
dc.subject | Receptors, CCR5 | en |
dc.subject | Antiretroviral Therapy, Highly Active | en |
dc.subject | green fluorescent protein | en |
dc.subject | Killer Cells, Natural | en |
dc.subject | molecular cloning | en |
dc.subject | Antigens, CD56 | en |
dc.subject | virus expression | en |
dc.subject | RNA viruses | en |
dc.subject | persistent virus infection | en |
dc.subject | Antigens, CD4 | en |
dc.subject | Lymphocyte Subsets | en |
dc.subject | Receptors, CXCR4 | en |
dc.subject | virus purification | en |
dc.title | Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1073/pnas.102672999 | |
dc.description.volume | 99 | |
dc.description.startingpage | 7015 | |
dc.description.endingpage | 7020 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :115</p> | en |
dc.source.abbreviation | Proc.Natl.Acad.Sci.U.S.A. | en |
dc.contributor.orcid | Kostrikis, Leontios G. [0000-0002-5340-7109] | |
dc.gnosis.orcid | 0000-0002-5340-7109 | |