dc.contributor.author | Georgiou, Theoni K. | en |
dc.contributor.author | Patrickios, Costas S. | en |
dc.creator | Georgiou, Theoni K. | en |
dc.creator | Patrickios, Costas S. | en |
dc.date.accessioned | 2019-11-21T06:19:09Z | |
dc.date.available | 2019-11-21T06:19:09Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1525-7797 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55504 | |
dc.description.abstract | Five model conetworks based on cross-linked star ampholytic copolymers were synthesized by group transfer polymerization. The ampholytic copolymers were based on two hydrophilic monomers: the positively ionizable 2-(dimethylamino)ethyl methacrylate (DMAEMA) and the negatively ionizable methacrylic acid (MAA). Ethylene glycol dimethacrylate was used as the cross-linker. These five ampholytic model conetworks were isomers based on equimolar DMAEMA-MAA copolymer stars of different architectures: heteroarm (two), star block (two), and statistical. The two networks based on the homopolymer stars were also synthesized. The MAA units were introduced via the polymerization of tetrahydropyranyl methacrylate and the acid hydrolysis of the latter after network formation. All the precursors to the (co)networks were characterized in terms of their molecular weights using gel permeation chromatography (GPC). The mass of the extractables from the (co)networks was measured and characterized in terms of molecular weight and composition using GPC and proton nuclear magnetic resonance (1H NMR) spectroscopy, respectively. The degrees of swelling (DS) of all the ampholytic conetworks were measured as a function of pH and were found to present a minimum at a pH value which was taken as the isoelectric point, pI. The DS and the pI values did not present a dependence on conetwork architecture. Finally, DNA adsorption studies onto the ampholyte conetworks indicated that DNA binding was governed by electrostatics. © 2008 American Chemical Society. | en |
dc.source | Biomacromolecules | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-39749088697&doi=10.1021%2fbm701123s&partnerID=40&md5=b2594df3a8f3d99b3bc4ca708cdf7215 | |
dc.subject | article | en |
dc.subject | Male | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | unclassified drug | en |
dc.subject | Animals | en |
dc.subject | DNA | en |
dc.subject | Polymers | en |
dc.subject | molecular weight | en |
dc.subject | Synthesis (chemical) | en |
dc.subject | synthesis | en |
dc.subject | Characterization | en |
dc.subject | Copolymers | en |
dc.subject | Crosslinking | en |
dc.subject | Homopolymerization | en |
dc.subject | chemical structure | en |
dc.subject | complex formation | en |
dc.subject | copolymer | en |
dc.subject | Group transfer polymerization | en |
dc.subject | methacrylic acid derivative | en |
dc.subject | proton nuclear magnetic resonance | en |
dc.subject | polymerization | en |
dc.subject | electricity | en |
dc.subject | cross linking | en |
dc.subject | structure activity relation | en |
dc.subject | Hydrolysis | en |
dc.subject | isomer | en |
dc.subject | Fishes | en |
dc.subject | DNA binding | en |
dc.subject | ethylene glycol dimethacrylate | en |
dc.subject | Gel permeation chromatography | en |
dc.subject | methacrylic acid dimethylaminoethyl ester | en |
dc.subject | Models, Chemical | en |
dc.subject | hydrophilicity | en |
dc.subject | ampholyte | en |
dc.subject | adsorption | en |
dc.subject | Ampholytic model conetworks | en |
dc.subject | Cross-Linking Reagents | en |
dc.subject | isoelectric point | en |
dc.subject | Methacrylic acid | en |
dc.subject | nonviral gene delivery system | en |
dc.subject | pH measurement | en |
dc.subject | tetrahydropyranyl methacrylate | en |
dc.title | Synthesis, characterization, and DNA adsorption studies of ampholytic model conetworks based on cross-linked star copolymers | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1021/bm701123s | |
dc.description.volume | 9 | |
dc.description.issue | 2 | |
dc.description.startingpage | 574 | |
dc.description.endingpage | 582 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Manufacturers: Aldrich, Germany | en |
dc.description.notes | Cited By :43</p> | en |
dc.source.abbreviation | Biomacromolecules | en |
dc.contributor.orcid | Patrickios, Costas S. [0000-0001-8855-0370] | |
dc.contributor.orcid | Georgiou, Theoni K. [0000-0003-4474-6931] | |
dc.gnosis.orcid | 0000-0001-8855-0370 | |
dc.gnosis.orcid | 0000-0003-4474-6931 | |