dc.contributor.author | Ioannidou, Heraklidia A. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Ioannidou, Heraklidia A. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:25Z | |
dc.date.available | 2019-11-21T06:19:25Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1523-7060 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55563 | |
dc.description.abstract | Silver(I) fluoride-mediated Pd-catalyzed C-H direct arylation/ heteroarylation of 3-bromoisothiazole-4-carbonitrile (1a) gives twenty-four 5-aryl/heteroaryl-3-bromoisothiazole-4-carbonitriles. The reaction was partially optimized with respect to catalyst, ligand, and base. During this study 3,3′-dibromo-5,5′-biisothiazole-4,4′-dicarbonitrile (3a) was isolated as a byproduct and subsequently prepared via the silver-mediated Pd-catalyzed oxidative dimerization of 3-bromoisothiazole-4-carbonitrile in 67% yield. The analogous phenylation and oxidative dimerization of 3-chloroisothiazole-4-carbonitrile (1b) gave 3-chloro-5-phenylisothiazole-4- carbonitrile (4) and 3,3′-dichloro-5,5′-biisothiazole-4,4′- dicarbonitrile (3b) in 96% and 69% yields, respectively. © 2011 American Chemical Society. | en |
dc.source | Organic letters | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952612354&doi=10.1021%2fol200196m&partnerID=40&md5=e0fd80af49a954c213ffad45733a82cb | |
dc.subject | article | en |
dc.subject | Nitriles | en |
dc.subject | chemistry | en |
dc.subject | nitrile | en |
dc.subject | synthesis | en |
dc.subject | chemical structure | en |
dc.subject | catalysis | en |
dc.subject | palladium | en |
dc.subject | Molecular Structure | en |
dc.subject | thiazole derivative | en |
dc.subject | Thiazoles | en |
dc.subject | 3 bromoisothiazole 4 carbonitrile | en |
dc.subject | 3-bromoisothiazole-4-carbonitrile | en |
dc.subject | fluoride | en |
dc.subject | Fluorides | en |
dc.subject | Silver Compounds | en |
dc.subject | silver derivative | en |
dc.subject | silver fluoride | en |
dc.title | Silver-mediated palladium-catalyzed direct C-H arylation of 3-bromoisothiazole-4-carbonitrile | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1021/ol200196m | |
dc.description.volume | 13 | |
dc.description.issue | 6 | |
dc.description.startingpage | 1510 | |
dc.description.endingpage | 1513 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :19</p> | en |
dc.source.abbreviation | Org.Lett. | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |