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dc.contributor.authorPapadopoulos, Minas S.en
dc.contributor.authorNock, B.en
dc.contributor.authorMaina-Nock, Theodosiaen
dc.contributor.authorPirmettis, Ioannis C.en
dc.contributor.authorRaptopoulou, Catherine P.en
dc.contributor.authorTasiopoulos, Anastasios J.en
dc.contributor.authorTroganis, Anastassios N.en
dc.contributor.authorKabanos, Themistoklis A.en
dc.contributor.authorTerzis, Arisen
dc.contributor.authorChiotellis, Efstratiosen
dc.creatorPapadopoulos, Minas S.en
dc.creatorNock, B.en
dc.creatorMaina-Nock, Theodosiaen
dc.creatorPirmettis, Ioannis C.en
dc.creatorRaptopoulou, Catherine P.en
dc.creatorTasiopoulos, Anastasios J.en
dc.creatorTroganis, Anastassios N.en
dc.creatorKabanos, Themistoklis A.en
dc.creatorTerzis, Arisen
dc.creatorChiotellis, Efstratiosen
dc.date.accessioned2019-11-21T06:21:57Z
dc.date.available2019-11-21T06:21:57Z
dc.date.issued2001
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55950
dc.description.abstractNovel oxorhenium and oxotechnetium complexes based on the tetradentate 1-(2-hydroxybenzamido)-2-(pyridinecarboxamido)benzene, H3L, ligand have been synthesized and characterized herein. Thus, by reacting equimolar quantities of the triply deprotonated ligand L 3- with the suitable MO3+ precursor, the following neutral MOL complexes could be easily produced following similar synthetic routes: M=Re (1), M=99gTc (2), and M=99mTc (3). Complexes 1 and 2, prepared in macroscopic amounts, were chemically characterized and their structure determined by singlecrystal X-ray analysis. They are isostructural metal chelates, adopting a distorted square pyramidal geometry around the metal. The N3O donor atom set of the tetradentate ligand defines the basal plane and the oxygen atom of the M=O core occupies the apex of the pyramid. Complex 3 forms quantitatively at tracer level by mixing the H3L ligand with Na99mTcO4 generator eluate in aqueous alkaline media and using tin chloride as reductant in the presence of citrate. Its structure was established by chromatographic comparison with prototypic complexes 1 and 2 using high-performance liquid chromatographic techniques. When challenged with excess glutathione in vitro, complex 3 is rapidly converted to hydrophilic unidentified metal species. Tissue distribution data after administration of complex 3 in vivo revealed a significant uptake and retention of this compound in brain tissue.en
dc.sourceJournal of Biological Inorganic Chemistryen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-17944379444&doi=10.1007%2fs007750000186&partnerID=40&md5=91ec13452766c89fd7e375efc31c2958
dc.subjectarticleen
dc.subjectcontrolled studyen
dc.subjectpriority journalen
dc.subjectmaleen
dc.subjectunclassified drugen
dc.subjectnonhumanen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectanimal experimenten
dc.subjectmouseen
dc.subjectOrganotechnetium Compoundsen
dc.subjecttissue distributionen
dc.subjectdrug distributionen
dc.subjectRadiopharmaceuticalsen
dc.subjectdrug synthesisen
dc.subjectRheniumen
dc.subjectstructure analysisen
dc.subjectBrainen
dc.subjectOxidation-Reductionen
dc.subjectX ray analysisen
dc.subjectdrug retentionen
dc.subjectDrug Stabilityen
dc.subjectAnimaliaen
dc.subjectOrganometallic Compoundsen
dc.subjectdrug structureen
dc.subjectCrystallography, X-Rayen
dc.subjectchromatographyen
dc.subjectmetal derivativeen
dc.subjectglutathioneen
dc.subjectBrain perfusionen
dc.subjectbrain tissueen
dc.subjectdrug uptakeen
dc.subjectoxorhenium complexen
dc.subjectoxotechnetium complexen
dc.subjectRetention mechanismen
dc.subjectTechnetiumen
dc.subjecttechnetium derivativeen
dc.subjectTechnetium-99m agenten
dc.titleNovel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: Synthesis, characterization and biological evaluationen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s007750000186
dc.description.volume6
dc.description.issue2
dc.description.startingpage159
dc.description.endingpage165
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :15</p>en
dc.source.abbreviationJ.Biol.Inorg.Chem.en
dc.contributor.orcidTasiopoulos, Anastasios J. [0000-0002-4804-3822]
dc.contributor.orcidKabanos, Themistoklis A. [0000-0001-6944-5153]
dc.contributor.orcidRaptopoulou, Catherine P. [0000-0002-8775-5427]
dc.gnosis.orcid0000-0002-4804-3822
dc.gnosis.orcid0000-0001-6944-5153
dc.gnosis.orcid0000-0002-8775-5427


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