dc.contributor.author | Papadopoulos, Minas S. | en |
dc.contributor.author | Nock, B. | en |
dc.contributor.author | Maina-Nock, Theodosia | en |
dc.contributor.author | Pirmettis, Ioannis C. | en |
dc.contributor.author | Raptopoulou, Catherine P. | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Troganis, Anastassios N. | en |
dc.contributor.author | Kabanos, Themistoklis A. | en |
dc.contributor.author | Terzis, Aris | en |
dc.contributor.author | Chiotellis, Efstratios | en |
dc.creator | Papadopoulos, Minas S. | en |
dc.creator | Nock, B. | en |
dc.creator | Maina-Nock, Theodosia | en |
dc.creator | Pirmettis, Ioannis C. | en |
dc.creator | Raptopoulou, Catherine P. | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Troganis, Anastassios N. | en |
dc.creator | Kabanos, Themistoklis A. | en |
dc.creator | Terzis, Aris | en |
dc.creator | Chiotellis, Efstratios | en |
dc.date.accessioned | 2019-11-21T06:21:57Z | |
dc.date.available | 2019-11-21T06:21:57Z | |
dc.date.issued | 2001 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55950 | |
dc.description.abstract | Novel oxorhenium and oxotechnetium complexes based on the tetradentate 1-(2-hydroxybenzamido)-2-(pyridinecarboxamido)benzene, H3L, ligand have been synthesized and characterized herein. Thus, by reacting equimolar quantities of the triply deprotonated ligand L 3- with the suitable MO3+ precursor, the following neutral MOL complexes could be easily produced following similar synthetic routes: M=Re (1), M=99gTc (2), and M=99mTc (3). Complexes 1 and 2, prepared in macroscopic amounts, were chemically characterized and their structure determined by singlecrystal X-ray analysis. They are isostructural metal chelates, adopting a distorted square pyramidal geometry around the metal. The N3O donor atom set of the tetradentate ligand defines the basal plane and the oxygen atom of the M=O core occupies the apex of the pyramid. Complex 3 forms quantitatively at tracer level by mixing the H3L ligand with Na99mTcO4 generator eluate in aqueous alkaline media and using tin chloride as reductant in the presence of citrate. Its structure was established by chromatographic comparison with prototypic complexes 1 and 2 using high-performance liquid chromatographic techniques. When challenged with excess glutathione in vitro, complex 3 is rapidly converted to hydrophilic unidentified metal species. Tissue distribution data after administration of complex 3 in vivo revealed a significant uptake and retention of this compound in brain tissue. | en |
dc.source | Journal of Biological Inorganic Chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-17944379444&doi=10.1007%2fs007750000186&partnerID=40&md5=91ec13452766c89fd7e375efc31c2958 | |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | male | en |
dc.subject | unclassified drug | en |
dc.subject | nonhuman | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal experiment | en |
dc.subject | mouse | en |
dc.subject | Organotechnetium Compounds | en |
dc.subject | tissue distribution | en |
dc.subject | drug distribution | en |
dc.subject | Radiopharmaceuticals | en |
dc.subject | drug synthesis | en |
dc.subject | Rhenium | en |
dc.subject | structure analysis | en |
dc.subject | Brain | en |
dc.subject | Oxidation-Reduction | en |
dc.subject | X ray analysis | en |
dc.subject | drug retention | en |
dc.subject | Drug Stability | en |
dc.subject | Animalia | en |
dc.subject | Organometallic Compounds | en |
dc.subject | drug structure | en |
dc.subject | Crystallography, X-Ray | en |
dc.subject | chromatography | en |
dc.subject | metal derivative | en |
dc.subject | glutathione | en |
dc.subject | Brain perfusion | en |
dc.subject | brain tissue | en |
dc.subject | drug uptake | en |
dc.subject | oxorhenium complex | en |
dc.subject | oxotechnetium complex | en |
dc.subject | Retention mechanism | en |
dc.subject | Technetium | en |
dc.subject | technetium derivative | en |
dc.subject | Technetium-99m agent | en |
dc.title | Novel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: Synthesis, characterization and biological evaluation | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s007750000186 | |
dc.description.volume | 6 | |
dc.description.issue | 2 | |
dc.description.startingpage | 159 | |
dc.description.endingpage | 165 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :15</p> | en |
dc.source.abbreviation | J.Biol.Inorg.Chem. | en |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Kabanos, Themistoklis A. [0000-0001-6944-5153] | |
dc.contributor.orcid | Raptopoulou, Catherine P. [0000-0002-8775-5427] | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0001-6944-5153 | |
dc.gnosis.orcid | 0000-0002-8775-5427 | |