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dc.contributor.authorPashalidis, Ioannisen
dc.contributor.authorKontoghiorghes, G. J.en
dc.creatorPashalidis, Ioannisen
dc.creatorKontoghiorghes, G. J.en
dc.date.accessioned2019-11-21T06:22:03Z
dc.date.available2019-11-21T06:22:03Z
dc.date.issued2001
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55970
dc.description.abstractDeferiprone (1,2-dimethyl-3-hydroxypyrid-4-one, L1, CAS 30652-11-0) is a new chelating drug used worldwide for the treatment of iron overloading conditions. Spectrophotometric and potentiometric measurements were carried out to investigate the interaction of L1 with Cu(II) ions under different conditions. The complexation of Cu(II) ions with L1 in aqueous solution leads predominantly to the formation of the Cu(L1)2 species at a pH range of 4-9. The experimental results indicate that L1 has high affinity for Cu(II) with stability constants logβ11 = 10.3 ± 0.9 and logβ12 = 19.2 ± 0.6. The effect of Cu(II) ions on the affinity of L1 for Fe(III) ions by competition reactions in vitro indicate displacement of Fe(III) in a concentration dependent manner by Cu(II). Similarly, the presence of different buffers at various pH values resulted in the formation of different stoichiometry L1 complexes with Cu(II) and of mixed complexes with buffer anions. The strong interaction of L1 with Cu(II) may have implications on the therapeutic and toxicological properties of this chelating drug. In particular, L1 may be used in the treatment of copper overloading conditions, such as Wilson's disease or other conditions where copper toxicity is implicated.en
dc.sourceArzneimittel-Forschung/Drug Researchde
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035664696&partnerID=40&md5=f8a029cf6c5e1f67b74f1af23b8992b4
dc.subjectarticleen
dc.subjectAlgorithmsen
dc.subjectbinding affinityen
dc.subjectmolecular biologyen
dc.subjectIronen
dc.subjectIron Chelating Agentsen
dc.subjectPyridonesen
dc.subjectstoichiometryen
dc.subjectaqueous solutionen
dc.subjectcomplex formationen
dc.subjectpHen
dc.subjectconcentration responseen
dc.subjectHydrogen-Ion Concentrationen
dc.subjectchelating agenten
dc.subjectCopperen
dc.subjectbufferen
dc.subjectBuffersen
dc.subjectSpectrophotometry, Ultravioleten
dc.subjectbinding competitionen
dc.subjectBinding, Competitiveen
dc.subjectanionen
dc.subjectpotentiometryen
dc.subjectspectrophotometryen
dc.subjectdeferiproneen
dc.subjectcopper complexen
dc.subjectCAS 30652-11-0en
dc.subjectCopper, competitionen
dc.subjectDeferiprone, metal complexes, stability constantsen
dc.subjectL1en
dc.titleMolecular factors affecting the complex formation between deferiprone (L1) and Cu(II): Possible implications on efficacy and toxicityen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume51
dc.description.issue12
dc.description.startingpage998
dc.description.endingpage1003
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :11</p>en
dc.source.abbreviationArzneim.-Forsch.Drug Res.en
dc.contributor.orcidPashalidis, Ioannis [0000-0002-7587-6395]
dc.gnosis.orcid0000-0002-7587-6395


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