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ICPBCZin: A red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions

dc.contributor.authorRoussakis, E.en
dc.contributor.authorVoutsadaki, S.en
dc.contributor.authorPinakoulaki, Eftychiaen
dc.contributor.authorSideris, D. P.en
dc.contributor.authorTokatlidis, K.en
dc.contributor.authorKaterinopoulos, H. E.en
dc.creatorRoussakis, E.en
dc.creatorVoutsadaki, S.en
dc.creatorPinakoulaki, Eftychiaen
dc.creatorSideris, D. P.en
dc.creatorTokatlidis, K.en
dc.creatorKaterinopoulos, H. E.en
dc.date.accessioned2019-11-21T06:22:39Z
dc.date.available2019-11-21T06:22:39Z
dc.date.issued2008
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/56094
dc.description.abstractA new fluorescent Zn2+ indicator, namely, ICPBCZin was synthesized and the spectral profile of its free and Zn2+ bound forms was studied. The newly synthesized zinc indicator incorporates as chromophore the chromeno [3′,2′:3,4]pyrido[1,2a] [1,3]benzimidazole moiety and belongs to the dicarboxylate-type of zinc probes. The compound is excited with visible light, exhibits high selectivity for zinc in the presence of calcium and other common biological ions, and its Zn2+ dissociation constant is 4.0 nM. Fluorescence spectra studies of ICPBCZin indicated a clear shift in its emission wavelength maxima upon Zn2+ binding, as it belongs to the class of Photoinduced Charge Transfer (PCT) indicators, along with changes in fluorescence intensity that enable the compound to be used as a ratiometric, visible-excitable Zn2+ probe. © 2007 Elsevier Ltd. All rights reserved.en
dc.sourceCell calciumen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-49549085487&doi=10.1016%2fj.ceca.2007.12.008&partnerID=40&md5=6397630b0aff2844a113ed0db04d487d
dc.subjectarticleen
dc.subjectcontrolled studyen
dc.subjectpriority journalen
dc.subjectnonhumanen
dc.subjectbinding affinityen
dc.subjectsynthesisen
dc.subjectchemical structureen
dc.subjectnuclear magnetic resonance spectroscopyen
dc.subjectinfrared spectroscopyen
dc.subjectcalcium ionen
dc.subjectfluorescence analysisen
dc.subjectchromatophoreen
dc.subjectbenzimidazole derivativeen
dc.subjectzinc ionen
dc.subjectcell membrane permeabilityen
dc.subjectconfocal microscopyen
dc.subjectdicarboxylic aciden
dc.subjectdissociation constanten
dc.subjectFluorescent dyeen
dc.subjectIntacellular zincen
dc.subjectphotostimulationen
dc.subjectRatiometric probeen
dc.subjectsalicylaldehydeen
dc.subjectyeast cellen
dc.subjectZinc ion sensoren
dc.titleICPBCZin: A red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ionsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ceca.2007.12.008
dc.description.volume44
dc.description.issue3
dc.description.startingpage270
dc.description.endingpage275
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :17</p>en
dc.source.abbreviationCell Calciumen
dc.contributor.orcidPinakoulaki, Eftychia [0000-0003-3320-6112]
dc.gnosis.orcid0000-0003-3320-6112


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