dc.contributor.author | Shpakovsky, D. B. | en |
dc.contributor.author | Banti, Christina N. | en |
dc.contributor.author | Beaulieu-Houle, G. | en |
dc.contributor.author | Kourkoumelis, Nikolaos | en |
dc.contributor.author | Manoli, Maria | en |
dc.contributor.author | Manos, Manolis J. | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Hadjikakou, Sotiris K. | en |
dc.contributor.author | Milaeva, E. R. | en |
dc.contributor.author | Charalabopoulos, Konstantinos A. | en |
dc.contributor.author | Bakas, Thomas V. | en |
dc.contributor.author | Butler, I. S. | en |
dc.contributor.author | Hadjiliadis, Nick | en |
dc.creator | Shpakovsky, D. B. | en |
dc.creator | Banti, Christina N. | en |
dc.creator | Beaulieu-Houle, G. | en |
dc.creator | Kourkoumelis, Nikolaos | en |
dc.creator | Manoli, Maria | en |
dc.creator | Manos, Manolis J. | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Hadjikakou, Sotiris K. | en |
dc.creator | Milaeva, E. R. | en |
dc.creator | Charalabopoulos, Konstantinos A. | en |
dc.creator | Bakas, Thomas V. | en |
dc.creator | Butler, I. S. | en |
dc.creator | Hadjiliadis, Nick | en |
dc.date.accessioned | 2019-11-21T06:22:45Z | |
dc.date.available | 2019-11-21T06:22:45Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/56117 | |
dc.description.abstract | Four new organotin(iv) complexes of bis-(2,6-di-tert-butylphenol)tin(iv) dichloride [(tert-Bu-)2(HO-Ph)]2SnCl2 (1) with the heterocyclic thioamides 2-mercapto-pyrimidine (PMTH), 2-mercapto-4-methyl- pyrimidine (MPMTH), 2-mercapto-pyridine (PYTH) and 2-mercapto-benzothiazole (MBZTH), of formulae {[(tert-Bu-)2(HO-Ph)]2Sn(PMT) 2} (2), {[(tert-Bu-)2(HO-Ph)]2Sn(MPMT) 2} (3), {[(tert-Bu-)2(HO-Ph)]2SnCl(PYT)} (4) and {[(tert-Bu-)2(HO-Ph)]2SnCl(MBZT)} (5), have been synthesized and characterized by elemental analysis, 1H-, 13C-, 119Sn-NMR, EPR, FT-IR, Raman and Mössbauer spectroscopic techniques. The crystal and molecular structures of compounds 1-5 have been determined by X-ray diffraction. The geometries around the metal center adopted in complexes 1-5 varied between tetrahedral in 1, trigonal bipyramidal in 3, 4, 5 and distorted octahedral in 2. Two carbon atoms from aryl groups and two chlorine atoms form a distorted tetrahedron in the case of 1. Two carbon, two sulfur and two nitrogen atoms from thione ligands form a distorted octahedral geometry around tin(iv) with trans-C2, cis-N2, cis-S2-configurations in 2. However, in the case of 4 and 5 complexes two carbon, one sulfur, one nitrogen and one chloride atom form a distorted trigonal bipyramidal arrangement. Finally, in the case of 3 the trigonal bipyramidal geometry is achieved by two carbon, two sulfur and one nitrogen atom in a unique coordination mode of thioamides toward the tin(iv) cation. Compounds 1-5 were tested for their in vitro cytotoxicity against the human breast adenocarcinoma (MCF-7) cell line. Compound 3 exhibits strong cytotoxic activity against MCF-7 cells (IC50 = 0.58 ± 0.1 μM). © 2012 The Royal Society of Chemistry. | en |
dc.source | Dalton Transactions | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870026803&doi=10.1039%2fc2dt31527k&partnerID=40&md5=6c73d8ae231734c8b305a10b09a90a2a | |
dc.subject | Geometry | en |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | Breast Neoplasms | en |
dc.subject | female | en |
dc.subject | drug effect | en |
dc.subject | Computational Biology | en |
dc.subject | pathology | en |
dc.subject | metabolism | en |
dc.subject | drug screening | en |
dc.subject | cell survival | en |
dc.subject | Pyrimidines | en |
dc.subject | chemistry | en |
dc.subject | breast tumor | en |
dc.subject | Cytotoxicity | en |
dc.subject | cell strain MCF 7 | en |
dc.subject | HeLa cell | en |
dc.subject | biology | en |
dc.subject | Synthesis (chemical) | en |
dc.subject | synthesis | en |
dc.subject | Chlorine compounds | en |
dc.subject | Carbon | en |
dc.subject | X ray diffraction | en |
dc.subject | Mossbauer | en |
dc.subject | X ray crystallography | en |
dc.subject | Molybdenum | en |
dc.subject | Chlorine | en |
dc.subject | Tin | en |
dc.subject | Structural characterization | en |
dc.subject | Nitrogen | en |
dc.subject | Cell culture | en |
dc.subject | tumor cell line | en |
dc.subject | In-vitro | en |
dc.subject | Molecular Conformation | en |
dc.subject | conformation | en |
dc.subject | Coordination Complexes | en |
dc.subject | coordination compound | en |
dc.subject | Organometallics | en |
dc.subject | Sulfur | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Drug Screening Assays, Antitumor | en |
dc.subject | MCF-7 cells | en |
dc.subject | isomerism | en |
dc.subject | Crystallography, X-Ray | en |
dc.subject | HeLa Cells | en |
dc.subject | Atoms | en |
dc.subject | Aromatic compounds | en |
dc.subject | principal component analysis | en |
dc.subject | Octahedral geometry | en |
dc.subject | pyrimidine derivative | en |
dc.subject | Molybdenum compounds | en |
dc.subject | thioamide | en |
dc.subject | Thioamides | en |
dc.subject | Carbon atoms | en |
dc.subject | 2 ,6-Di-tert-butylphenol | en |
dc.subject | 2-mercapto-benzothiazole | en |
dc.subject | Aryl group | en |
dc.subject | Cell lines | en |
dc.subject | Chlorine atom | en |
dc.subject | Coordination modes | en |
dc.subject | Crystal and molecular structure | en |
dc.subject | Cytotoxic activities | en |
dc.subject | Human breast | en |
dc.subject | Human breast cancer | en |
dc.subject | Metal centers | en |
dc.subject | Nitrogen atom | en |
dc.subject | Organotin complex | en |
dc.subject | pyrimidine | en |
dc.subject | Spectroscopic technique | en |
dc.subject | Trigonal bipyramidal | en |
dc.subject | Trigonal bipyramidal geometry | en |
dc.title | Synthesis, structural characterization and in vitro inhibitory studies against human breast cancer of the bis-(2,6-di-tert-butylphenol)tin(iv) dichloride and its complexes | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1039/c2dt31527k | |
dc.description.volume | 41 | |
dc.description.issue | 48 | |
dc.description.startingpage | 14568 | |
dc.description.endingpage | 14582 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :24</p> | en |
dc.source.abbreviation | Dalton Trans. | en |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Hadjikakou, Sotiris K. [0000-0001-9556-6266] | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0001-9556-6266 | |