• Master Thesis  Open Access

      Mechanisms underlying Trastuzumab Resistance in HER2-positive (HER2+) Breast Cancer and potential therapeutic approaches 

      Theodorou, Troodia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
      HER2-positive (HER2+) breast cancer is characterized by overexpression of HER2 (Human Epidermal Growth Factor Receptor 2) protein on the surface of cells in the breast's ducts or lobes. HER2 overexpression creates an ...
    • Master Thesis  Open Access

      MicroRNAs in Alzheimer's Disease: A Comprehensive Analysis and Therapeutic Implications 

      Lazaridou, Antrea (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
      Alzheimer's disease (AD) remains an enigmatic challenge in the field of neurodegenerative disorders, characterized by progressive cognitive decline and the accumulation of aberrant protein aggregates in the brain. This ...
    • Master Thesis  Open Access

      Modelling Glioblastoma Angiogenesis in Drosophila larvae 

      Konstantinou, Anna G. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
      Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
    • Master Thesis  Open Access

      Molecular mechanisms that Hepatitis B virus uses to induce Hepatocellular Carcinoma 

      Frangou, Antrea (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-07)
      Hepatitis B is an infectious liver disease caused by the Hepatitis B virus (HBV). HBV is a small DNA virus that mainly affects hepatocytes, which are the main liver cells, and it has the ability to replicate by reverse ...
    • Master Thesis  Open Access

      Molecular pathways affected by HBx protein and their targeting for therapy of Hepatocellular carcinoma 

      Ketti, Stavriani A. (2022-12-09)
      Hepatitis B virus (HBV) infection can cause several types of liver disease including acute hepatitis, chronic hepatitis, and liver cirrhosis. It is also considered a significant risk factor for Hepatocellular carcinoma ...
    • Master Thesis  Open Access

      The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation 

      Alshikh Saleh, Ahmad (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)
      Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...
    • Master Thesis  Open Access

      Novel molecular approaches to treat colorectal cancer 

      Argyrou, Christina (2021-12-10)
      Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...
    • Master Thesis  Open Access

      Novel therapeutic approaches targeting the molecular mechanisms governing SARS-CoV-2 infection 

      Chasikos, Ioannis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023)
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing worldwide pandemic of Coronavirus Disease 2019 (COVID-19), which remains a public health concern despite the successful ...
    • Master Thesis  Open Access

      The PINK1/Parkin-dependent mitophagy pathway and its role in Parkinson’s disease 

      Theodosiou, Irene (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)
      Parkinson's disease is the second most prevalent neurodegenerative disease, surpassed only by Alzheimer’s disease. The disease is relentless, progressive, and incurable, and there is a great need to understand its causes ...
    • Master Thesis  Open Access

      Prostate Cancer Organoids in the Fight Against Prostate Cancer 

      Panteli, Maria (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
      Prostate Cancer is one of the leading diseases that increase morbidity and mortality rates in men worldwide. Despite high intertumoral and inter-patient heterogeneity, prostate cancer is, in most cases, androgen-sensitive ...
    • Master Thesis  Open Access

      Quantifying the fragmentation levels of amphibian, reptile, and terrestrial mammal habitats inside and outside of Natura 2000 sites within the European Union 

      Economides, Sophia (2023-05-25)
      Natural landscapes are constantly being modified and fragmented through a plethora of human activities, such as urbanisation and agriculture. Landscape fragmentation can have multiple negative effects on biodiversity. For ...
    • Master Thesis  Open Access

      Recombinant Poliovirus a therapeutic agent for Cancer 

      Mbonu, Helen (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05)
      Cancer is a leading cause of global mortality, and its burden is growing despite the availability of standard treatment methods. Genetically and Morphologically tumor cells differ from normal cells. However, cancers arise ...
    • Master Thesis  Open Access

      Reproductive biology and growth of the alien Red Sea goatfish Parupeneus forsskali (Fourmanoir & Guézé, 1976) off the coast of Cyprus 

      Saemundsson, Sigurdur (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-15)
      Goatfish (family Mullidae) are of great commercial and economical importance around the world, including in the Mediterranean Sea, where six goatfish species have been recorded. Four of those species are alien to the ...
    • Master Thesis  Open Access

      Spatiotemporal vocal interactions in a ground-dwelling Neotropical passerine 

      Elia, Stavroula (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-11)
      In many species, communication involves an exchange of information between the sender and the receiver, by using different types of signals. Among the different types of communication, acoustic communication has been studied ...