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dc.contributor.authorBaish, J. W.en
dc.contributor.authorStylianopoulos, T.en
dc.contributor.authorLanning, R. M.en
dc.contributor.authorKamoun, W. S.en
dc.contributor.authorFukumura, D.en
dc.contributor.authorMunn, L. L.en
dc.contributor.authorJain, R. K.en
dc.creatorBaish, J. W.en
dc.creatorStylianopoulos, T.en
dc.creatorLanning, R. M.en
dc.creatorKamoun, W. S.en
dc.creatorFukumura, D.en
dc.creatorMunn, L. L.en
dc.creatorJain, R. K.en
dc.date.accessioned2019-05-06T12:23:24Z
dc.date.available2019-05-06T12:23:24Z
dc.date.issued2011
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48247
dc.description.abstractDelivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascular geometry - δmax and λ - readily obtained from vascular images, capture these differences and link vascular structure to delivery in both tissue types. The longest time needed to bring materials to their destination scales with the square of δmax, the maximum distance in the tissue from the nearest blood vessel, whereas λ, a measure of the shape of the spaces between vessels, determines the rate of delivery for shorter times. Our results are useful for evaluating how new therapeutic agents that inhibit or stimulate vascular growth alter the functional efficiency of the vasculature and more broadly for analysis of diffusion in irregularly shaped domains.en
dc.language.isoengen
dc.sourceProceedings of the National Academy of Sciences of the United States of Americaen
dc.subjectmodelen
dc.subjectarticleen
dc.subjectAntineoplastic Agentsen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectpriority journalen
dc.subjectdrug clearanceen
dc.subjectCanceren
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectcancer tissueen
dc.subjectsubcutaneous tissueen
dc.subjectdrug delivery systemen
dc.subjectDiffusionen
dc.subjectFractal dimensionen
dc.subjectAntiangiogenesisen
dc.subjectblood vesselen
dc.subjectdrug diffusionen
dc.subjectPercolationen
dc.subjectthermodynamicsen
dc.subjectTransporten
dc.titleScaling rules for diffusive drug delivery in tumor and normal tissuesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1073/pnas.1018154108
dc.description.volume108
dc.description.startingpage1799
dc.description.endingpage1803
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages1799-1803


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