dc.contributor.author | Apidianakis, Yiorgos | en |
dc.contributor.author | Mindrinos, M. N. | en |
dc.contributor.author | Xiao, W. | en |
dc.contributor.author | Tegos, G. P. | en |
dc.contributor.author | Papisov, M. I. | en |
dc.contributor.author | Hamblin, M. R. | en |
dc.contributor.author | Davis, R. W. | en |
dc.contributor.author | Tompkins, R. G. | en |
dc.contributor.author | Rahme, L. G. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.creator | Mindrinos, M. N. | en |
dc.creator | Xiao, W. | en |
dc.creator | Tegos, G. P. | en |
dc.creator | Papisov, M. I. | en |
dc.creator | Hamblin, M. R. | en |
dc.creator | Davis, R. W. | en |
dc.creator | Tompkins, R. G. | en |
dc.creator | Rahme, L. G. | en |
dc.date.accessioned | 2019-11-04T12:50:13Z | |
dc.date.available | 2019-11-04T12:50:13Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52935 | |
dc.description.abstract | Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and infection model was used to identify host genetic components that contribute to the hyper-susceptibility to infection that follows severe trauma. We show that P. aeruginosa compromises skeletal muscle gene (SMG) expression at the injury site to promote infection. We demonstrate that activation of 5MG structural components is under the control of clun-N-terminal Kinase (JNK) Kinase, Hemipterous (Hep), and activation of this pathway promotes local resistance to P. aeruginosa in flies and mice. Our study links SMG expression and function to increased susceptibility to infection, and suggests that P. aeruginosa affects SMG homeostasis locally by restricting SMG expression in injured skeletal muscle tissue. Local potentiation of these host responses, and/or inhibition of their suppression by virulent P. aeruginosa cells, could lead to novel therapies that prevent or treat deleterious and potentially fatal infections in severely injured individuals. © 2007 Apidianakis et al. | en |
dc.source | PLoS ONE | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-41949106708&doi=10.1371%2fjournal.pone.0001356&partnerID=40&md5=2e540e3237572f8b4c05c968820c025b | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | protein expression | en |
dc.subject | gene expression regulation | en |
dc.subject | nonhuman | en |
dc.subject | metabolism | en |
dc.subject | pathophysiology | en |
dc.subject | immune response | en |
dc.subject | Animals | en |
dc.subject | animal | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | mouse | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | skeletal muscle | en |
dc.subject | injury | en |
dc.subject | experimental model | en |
dc.subject | reverse transcription polymerase chain reaction | en |
dc.subject | protein function | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | Pseudomonas Infections | en |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | en |
dc.subject | scanning electron microscopy | en |
dc.subject | enzyme activation | en |
dc.subject | bacterial virulence | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | Mus | en |
dc.subject | homeostasis | en |
dc.subject | stress activated protein kinase | en |
dc.subject | bacterial cell | en |
dc.subject | fly | en |
dc.subject | gene induction | en |
dc.subject | Genes, Regulator | en |
dc.subject | genetic regulation | en |
dc.subject | Gram negative infection | en |
dc.subject | infection sensitivity | en |
dc.subject | injury severity | en |
dc.subject | MAP Kinase Kinase 4 | en |
dc.subject | mitogen activated protein kinase kinase 4 | en |
dc.subject | muscle injury | en |
dc.subject | muscle protein | en |
dc.subject | Muscle, Skeletal | en |
dc.subject | regulator gene | en |
dc.subject | smooth muscle protein | en |
dc.subject | troponin C | en |
dc.subject | wound infection | en |
dc.title | Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1371/journal.pone.0001356 | |
dc.description.volume | 2 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :28</p> | en |
dc.source.abbreviation | PLoS ONE | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 | |