Hedgehog restricts its expression domain in the Drosophila wing
dc.contributor.author | Bejarano, F. | en |
dc.contributor.author | Pérez, L. | en |
dc.contributor.author | Apidianakis, Yiorgos | en |
dc.contributor.author | Delidakis, Christos | en |
dc.contributor.author | Milán, M. | en |
dc.creator | Bejarano, F. | en |
dc.creator | Pérez, L. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.creator | Delidakis, Christos | en |
dc.creator | Milán, M. | en |
dc.date.accessioned | 2019-11-04T12:50:15Z | |
dc.date.available | 2019-11-04T12:50:15Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1469-221X | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52949 | |
dc.description.abstract | The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein Engrailed in posterior cells helps to generate this asymmetry by inducing the expression of Hh in the posterior compartment and, at the same time, repressing the expression of the essential downstream component Cubitus interruptus (Ci). Therefore, only anterior cells that receive the Hh signal across the compartment boundary will respond by stabilizing Ci. Here, we describe a new molecular mechanism that helps to maintain the Hh-expressing and Hh-responding cells in different non-overlapping cell populations. Master of thickveins (mtv) - A target of Hh activity encoding a nuclear zinc-finger protein - Is required to repress hh expression in anterior cells. Mtv exerts this action in a protein complex with Groucho (Gro) - The founding member of a superfamily of transcriptional corepressors that are conserved throughout eukaryotes. Therefore, Hh restricts its own expression domain in the Drosophila wing through the activity of Mtv and Gro. | en |
dc.source | EMBO reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34547644275&doi=10.1038%2fsj.embor.7401003&partnerID=40&md5=5e122552ce682e8c2d28f4672e18c8d8 | |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | unclassified drug | en |
dc.subject | nonhuman | en |
dc.subject | Animals | en |
dc.subject | protein targeting | en |
dc.subject | animal cell | en |
dc.subject | Hedgehog Proteins | en |
dc.subject | sonic hedgehog protein | en |
dc.subject | protein function | en |
dc.subject | molecular mechanics | en |
dc.subject | Erinaceidae | en |
dc.subject | Eukaryota | en |
dc.subject | protein domain | en |
dc.subject | eukaryote | en |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | en |
dc.subject | Cubitus interruptus | en |
dc.subject | Drosophila | en |
dc.subject | Drosophila Proteins | en |
dc.subject | groucho protein | en |
dc.subject | Repressor Proteins | en |
dc.subject | Wing | en |
dc.subject | cell population | en |
dc.subject | genetic code | en |
dc.subject | limb development | en |
dc.subject | Master of thickveins protein | en |
dc.subject | Nerve Growth Factors | en |
dc.subject | nuclear receptor corepressor | en |
dc.subject | protein family | en |
dc.subject | zinc finger protein | en |
dc.title | Hedgehog restricts its expression domain in the Drosophila wing | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1038/sj.embor.7401003 | |
dc.description.volume | 8 | |
dc.description.startingpage | 778 | |
dc.description.endingpage | 783 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :9</p> | en |
dc.source.abbreviation | EMBO Rep. | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 |
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