dc.contributor.author | Constantinou, Andreas I. | en |
dc.contributor.author | Mehta, R. | en |
dc.contributor.author | Husband, A. | en |
dc.creator | Constantinou, Andreas I. | en |
dc.creator | Mehta, R. | en |
dc.creator | Husband, A. | en |
dc.date.accessioned | 2019-11-04T12:50:22Z | |
dc.date.available | 2019-11-04T12:50:22Z | |
dc.date.issued | 2003 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52997 | |
dc.description.abstract | The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary organ culture (MMOC) model. Phenoxodiol (2H-1-benzopyran-7-O1,3-(4-hydroxyphenyl)), the most effective in this assay, was selected for further testing in female Sprague-Dawley rats. The agent was tested at 0 (basal diet), 50 and 75 mg/kg diet. Mammary carcinomas in these three groups were induced by dimethylbenz[a]anthracene (DMBA) injected 1 week after the animals started eating the experimental diets. Phenoxodiol significantly reduced tumour incidence rate at both doses (P≤0.05). Tumour latency was increased from 70.4 days in the control group to 92.9 (P=0.04) days and 97.8 (P=0.03) days in the groups that were fed 50 and 75 mg/kg phenoxodiol, respectively. Compared with the control that was fed basal diet, tumour multiplicity was reduced by 42% (P=0.04) in the group that was fed 50 mg/kg phenoxodiol and by 49% (P=0.01) in the group that was fed 75 mg/kg phenoxodiol. Two additional groups that were not exposed to DMBA, one fed the basal diet and the other a diet containing 75 mg/kg phenoxodiol, were free of tumours. These data suggest that phenoxodiol is an effective chemopreventive agent against DMBA-induced mammary carcinogenesis. © 2003 Elsevier Science Ltd. All rights reserved. | en |
dc.source | European journal of cancer | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037403574&doi=10.1016%2fS0959-8049%2803%2900124-2&partnerID=40&md5=f36ff638e13df0549daee316e948e35e | |
dc.subject | article | en |
dc.subject | antineoplastic agent | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | priority journal | en |
dc.subject | drug efficacy | en |
dc.subject | antineoplastic activity | en |
dc.subject | dose response | en |
dc.subject | biological model | en |
dc.subject | unclassified drug | en |
dc.subject | breast carcinoma | en |
dc.subject | Anticarcinogenic Agents | en |
dc.subject | cancer prevention | en |
dc.subject | Chemoprevention | en |
dc.subject | dietary intake | en |
dc.subject | nonhuman | en |
dc.subject | Animals | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | breast carcinogenesis | en |
dc.subject | chemoprophylaxis | en |
dc.subject | Phenols | en |
dc.subject | Tumor Cells, Cultured | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | isoflavone derivative | en |
dc.subject | Isoflavones | en |
dc.subject | rat | en |
dc.subject | rat strain | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Drug Screening Assays, Antitumor | en |
dc.subject | Benzopyrans | en |
dc.subject | Phenoxodiol | en |
dc.subject | 9,10-Dimethyl-1,2-benzanthracene | en |
dc.subject | dimethylbenz[a]anthracene | en |
dc.subject | 2h 1 benzopyran 7 o 1,3 (4 hydroxyphenyl) | en |
dc.subject | Cancer incidence | en |
dc.subject | Cancer prevention and carcinogen | en |
dc.subject | Carcinogens | en |
dc.subject | Diet | en |
dc.subject | Mammary Neoplasms, Animal | en |
dc.subject | Mammary tumours | en |
dc.title | Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/S0959-8049(03)00124-2 | |
dc.description.volume | 39 | |
dc.description.startingpage | 1012 | |
dc.description.endingpage | 1018 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Manufacturers: Novogen, Australia | en |
dc.description.notes | Cited By :34</p> | en |
dc.source.abbreviation | Eur.J.Cancer | en |
dc.contributor.orcid | Constantinou, Andreas I. [0000-0003-0365-1821] | |
dc.gnosis.orcid | 0000-0003-0365-1821 | |