Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives.
dc.contributor.author | Constantinou, Constantina | en |
dc.contributor.author | Hyatt, John Anthony | en |
dc.contributor.author | Vraka, Panayiota S. | en |
dc.contributor.author | Papas, Andreas M. | en |
dc.contributor.author | Papas, Konstantinos A. | en |
dc.contributor.author | Neophytou, Christiana M. | en |
dc.contributor.author | Hadjivassiliou, V. | en |
dc.contributor.author | Constantinou, Andreas I. | en |
dc.creator | Constantinou, Constantina | en |
dc.creator | Hyatt, John Anthony | en |
dc.creator | Vraka, Panayiota S. | en |
dc.creator | Papas, Andreas M. | en |
dc.creator | Papas, Konstantinos A. | en |
dc.creator | Neophytou, Christiana M. | en |
dc.creator | Hadjivassiliou, V. | en |
dc.creator | Constantinou, Andreas I. | en |
dc.date.accessioned | 2019-11-04T12:50:24Z | |
dc.date.available | 2019-11-04T12:50:24Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1532-7914 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53009 | |
dc.description.abstract | Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, gamma-, delta-tocopherols (alpha-TOC, beta-TOC, gamma-TOC, delta-TOC) and alpha-, beta-, gamma-, delta-tocotrienols (alpha-TT, beta-TT, gamma-TT, delta-TT)] and their corresponding succinate synthetic derivatives [alpha-, beta-, gamma-, delta-tocopheryl succinates and alpha-, beta-, gamma-, delta-tocotrienyl succinates (alpha-TS, beta-TS, gamma-TS, delta-TS)] to induce cell death in AR- (DU145 and PC3) and AR+ (LNCaP) prostate cancer cell lines. The most effective of all the natural homologs of vitamin E was determined to be delta-TT, whereas delta-TS was the most potent of all the natural and synthetic compounds of vitamin E examined. Both gamma-TT and delta-TT induced caspase activity selectively in AR+ LNCaP cells, suggesting a possible role for AR for the activation of caspase-dependent programmed cell death (CD-PCD). More important, however, gamma-TT, delta-TT, gamma-TS, and delta-TS activated dominant caspase-independent programmed cell death (CI-PCD) in all prostate cancer cell lines examined. Thus, vitamin E homologs and synthetic derivatives may find applications in the treatment of prostate tumors that are resistant to caspase-activating therapeutic agents. | en |
dc.source | Nutrition and cancer | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952518368&doi=10.1080%2f01635580903285130&partnerID=40&md5=38494f153822c4505519c837e1a687bf | |
dc.subject | article | en |
dc.subject | antineoplastic agent | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | drug effect | en |
dc.subject | Time Factors | en |
dc.subject | male | en |
dc.subject | cell proliferation | en |
dc.subject | pathology | en |
dc.subject | drug potentiation | en |
dc.subject | drug derivative | en |
dc.subject | metabolism | en |
dc.subject | comparative study | en |
dc.subject | drug screening | en |
dc.subject | apoptosis | en |
dc.subject | adjuvant chemotherapy | en |
dc.subject | time | en |
dc.subject | chemistry | en |
dc.subject | plant extract | en |
dc.subject | Drug Synergism | en |
dc.subject | Prostatic Neoplasms | en |
dc.subject | prostate tumor | en |
dc.subject | Caspases | en |
dc.subject | isolation and purification | en |
dc.subject | drug antagonism | en |
dc.subject | synthesis | en |
dc.subject | tumor cell line | en |
dc.subject | Plant Extracts | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Drug Screening Assays, Antitumor | en |
dc.subject | isomerism | en |
dc.subject | alpha tocopherol | en |
dc.subject | androgen receptor | en |
dc.subject | annatto | en |
dc.subject | Antineoplastic Agents, Phytogenic | en |
dc.subject | AR protein, human | en |
dc.subject | Bixaceae | en |
dc.subject | carotenoid | en |
dc.subject | Carotenoids | en |
dc.subject | caspase | en |
dc.subject | Chemotherapy, Adjuvant | en |
dc.subject | IC 50 | en |
dc.subject | Inhibitory Concentration 50 | en |
dc.subject | palm oil | en |
dc.subject | Plant Oils | en |
dc.subject | Receptors, Androgen | en |
dc.subject | tocotrienol, delta | en |
dc.subject | vegetable oil | en |
dc.subject | Vitamin E | en |
dc.title | Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives. | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1080/01635580903285130 | |
dc.description.volume | 61 | |
dc.description.startingpage | 864 | |
dc.description.endingpage | 874 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :29</p> | en |
dc.source.abbreviation | Nutr.Cancer | en |
dc.contributor.orcid | Constantinou, Andreas I. [0000-0003-0365-1821] | |
dc.gnosis.orcid | 0000-0003-0365-1821 |
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