dc.contributor.author | Felekkis, Kyriacos N. | en |
dc.contributor.author | Voskarides, Konstantinos | en |
dc.contributor.author | Dweep, H. | en |
dc.contributor.author | Sticht, C. | en |
dc.contributor.author | Gretz, N. | en |
dc.contributor.author | Constantinou-Deltas, Constantinos D. | en |
dc.creator | Felekkis, Kyriacos N. | en |
dc.creator | Voskarides, Konstantinos | en |
dc.creator | Dweep, H. | en |
dc.creator | Sticht, C. | en |
dc.creator | Gretz, N. | en |
dc.creator | Constantinou-Deltas, Constantinos D. | en |
dc.date.accessioned | 2019-11-04T12:50:33Z | |
dc.date.available | 2019-11-04T12:50:33Z | |
dc.date.issued | 2011 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53071 | |
dc.description.abstract | MicroRNAs (miRNAs) and copy number variations (CNVs) are two newly discovered genetic elements that have revolutionized the field of molecular biology and genetics. By performing in silico whole genome analysis, we demonstrate that both the number of miRNAs that target genes found in CNV regions as well as the number of miRNA-binding sites are significantly higher than those of genes found in non-CNV regions. This suggests that miRNAs may have acted as equilibrators of gene expression during evolution in an attempt to regulate aberrant gene expression and to increase the tolerance to genome plasticity. © 2011 The Author. | en |
dc.source | Molecular biology and evolution | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052150067&doi=10.1093%2fmolbev%2fmsr078&partnerID=40&md5=e665a6ec2ace862fc111355cf5f081e1 | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | Computational Biology | en |
dc.subject | Gene Expression Regulation | en |
dc.subject | nonhuman | en |
dc.subject | gene expression | en |
dc.subject | microRNA | en |
dc.subject | gene targeting | en |
dc.subject | MicroRNAs | en |
dc.subject | molecular biology | en |
dc.subject | computer model | en |
dc.subject | gene interaction | en |
dc.subject | Evolution, Molecular | en |
dc.subject | genetic code | en |
dc.subject | Genome, Human | en |
dc.subject | binding site | en |
dc.subject | copy number variation | en |
dc.subject | RNA binding | en |
dc.subject | 3' Untranslated Regions | en |
dc.subject | Databases, Genetic | en |
dc.subject | DNA Copy Number Variations | en |
dc.subject | molecular evolution | en |
dc.title | Increased number of MicroRNA target sites in genes encoded in CNV regions. Evidence for an evolutionary genomic interaction | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1093/molbev/msr078 | |
dc.description.volume | 28 | |
dc.description.startingpage | 2421 | |
dc.description.endingpage | 2424 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :25</p> | en |
dc.source.abbreviation | Mol.Biol.Evol. | en |
dc.contributor.orcid | Constantinou-Deltas, Constantinos D. [0000-0001-5549-9169] | |
dc.gnosis.orcid | 0000-0001-5549-9169 | |