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dc.contributor.authorHatzakis, Angelos E.en
dc.contributor.authorTouloumi, G.en
dc.contributor.authorKaranicolas, R.en
dc.contributor.authorKarafoulidou, A.en
dc.contributor.authorMandalaki, T.en
dc.contributor.authorAnastassopoulou, C. G.en
dc.contributor.authorZhang, L.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorHo, David D.en
dc.contributor.authorKostrikis, Leontios G.en
dc.creatorHatzakis, Angelos E.en
dc.creatorTouloumi, G.en
dc.creatorKaranicolas, R.en
dc.creatorKarafoulidou, A.en
dc.creatorMandalaki, T.en
dc.creatorAnastassopoulou, C. G.en
dc.creatorZhang, L.en
dc.creatorGoedert, J. J.en
dc.creatorHo, David D.en
dc.creatorKostrikis, Leontios G.en
dc.date.accessioned2019-11-04T12:50:42Z
dc.date.available2019-11-04T12:50:42Z
dc.date.issued2000
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53125
dc.description.abstractBackground. The concentration of T-cell receptor-rearrangement excision DNA circles (TREC) in peripheral-blood T cells is a marker of recent thymic emigrant αβ T cells. We studied the predictive ability of measurements of TREC for clinical outcome in HIV-1-infected individuals. Methods. We measured TREC in peripheral-blood mononuclear cells with a real-time PCR assay. We studied 131 Greek participants in the Multicenter Hemophilia Cohort Study who had known HIV-1 seroconversion dates. The prognostic value of baseline TREC, CD4 T-cell count, and HIV-1 RNA concentration was assessed by Kaplan-Meier and Cox's regression analysis. Findings. Four participants had progressed to AIDS by first blood sampling. Among the remaining 127 individuals, the median value of TREC per 106 cells was 6900 (IQR 2370-15,604). Baseline TREC values were lower in the 53 who progressed to AIDS than in those who did not (geometric mean 2843 [95% CI 1468-5504] vs 6560 [4723-9113] per 106 cellsen
dc.description.abstractp = 0.007). The relative hazard of AIDS, adjusted for plasma viral load, CD4 T-cell count, and age at seroconversion was 1.44 (95% CI 1.04-2.01en
dc.description.abstractp = 0.031) per ten-fold increase in TRECen
dc.description.abstractthat for death was 1.52 (1.12-2.06en
dc.description.abstractp = 0.007). The adjusted relative hazards of death were 2.91 (1.91-4.44en
dc.description.abstractp < 0.001) per ten-fold increase in plasma HIV-1 RNA load and 1.20 (1.04-1.38en
dc.description.abstractp = 0.014) per 100-cell decrease in CD4 T-cell count. Interpretation. The concentration of TREC in the peripheral T-cell pool complements HIV-1 RNA load and CD4 T-cell count in predicting the rate of HIV-1 disease progression. Recent thymic emigrants have a role in the pathogenesis of HIV-1 disease.en
dc.sourceLanceten
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0034685170&partnerID=40&md5=60b599c5240a5f46fc27f84895b721b2
dc.subjectregression analysisen
dc.subjectarticleen
dc.subjectMaleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectadulten
dc.subjectageden
dc.subjectcontrolled studyen
dc.subjectmajor clinical studyen
dc.subjectDisease Progressionen
dc.subjectpriority journalen
dc.subjectadolescenten
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectdisease courseen
dc.subjectmortalityen
dc.subjectHIV Infectionsen
dc.subjectblood samplingen
dc.subjecthuman cellen
dc.subjectT-Lymphocytesen
dc.subjectlymphocyte counten
dc.subjectvirus loaden
dc.subjectvirus RNAen
dc.subjectpolymerase chain reactionen
dc.subjectHIV Seropositivityen
dc.subjectmononuclear cellen
dc.subjectschool childen
dc.subjectHuman immunodeficiency virus 1en
dc.subjectHIV-1en
dc.subjectacquired immune deficiency syndromeen
dc.subjectseroconversionen
dc.subjecthemophiliaen
dc.subjectRNA, Viralen
dc.subjectthymusen
dc.subjectThymus Glanden
dc.subjectCD4 Lymphocyte Counten
dc.subjectT lymphocyte receptoren
dc.subjectGene Rearrangement, T-Lymphocyteen
dc.subjectHemophilia Aen
dc.subjectReceptors, Antigen, T-Cell, alpha-betaen
dc.titleEffect of recent thymic emigrants on progression of HIV-1 diseaseen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume355
dc.description.startingpage599
dc.description.endingpage604
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :80</p>en
dc.source.abbreviationLanceten
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]
dc.gnosis.orcid0000-0002-5340-7109


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