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dc.contributor.authorHatzakis, Angelos E.en
dc.contributor.authorTouloumi, G.en
dc.contributor.authorPantazis, N.en
dc.contributor.authorAnastassopoulou, C. G.en
dc.contributor.authorKatsarou, O.en
dc.contributor.authorKarafoulidou, A.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorKostrikis, Leontios G.en
dc.creatorHatzakis, Angelos E.en
dc.creatorTouloumi, G.en
dc.creatorPantazis, N.en
dc.creatorAnastassopoulou, C. G.en
dc.creatorKatsarou, O.en
dc.creatorKarafoulidou, A.en
dc.creatorGoedert, J. J.en
dc.creatorKostrikis, Leontios G.en
dc.date.accessioned2019-11-04T12:50:42Z
dc.date.available2019-11-04T12:50:42Z
dc.date.issued2004
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53126
dc.description.abstractObjective: To assess whether cellular HIV-1 DNA prior to highly active antiretroviral therapy (HAART) initiation predicts its outcome. Design and methods: Patients included all 51 hemophiliacs of the Greek component of the Multicenter Hemophilia Cohort Study who had initiated HAART and for whom cryopreserved lymphocyte samples before HAART initiation were available. Cellular HIV-1 DNA quantification was performed by a molecular beacon-based real-time PCR assay in multiple samples per patient with a median (interquartile range) follow-up of 76 (45-102) weeks. Results: The median (range) baseline HIV-1 DNA load was 297 (< 10 to 3468) copies per 1 × 106 peripheral blood mononuclear cells. Baseline HIV-1 DNA load did not predict initial virological response (VR). None of the patients with initial VR and baseline HIV-1 DNA load at or below the median experienced a subsequent virological rebound, while the cumulative probability of virological rebound by week 104 was 55% among those with HIV-1 DNA load greater than the median (P<0.008). Cellular HIV-1 DNA load was the only parameter associated with sustained virological response as shown by univariate or multivariate analyses [adjusted odds ratio (95% confidence interval) 0.197 (0.048-0.801) per 1 log10 increase in DNA copies, P = 0.023]. Conclusion: Low cellular HIV-1 DNA load is a marker of sustained virological response in patients with initial VR and it can reliably predict the long-term success of HAART. © 2004 Lippincott Williams & Wilkins.en
dc.sourceAIDSen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-10244229643&doi=10.1097%2f00002030-200411190-00006&partnerID=40&md5=e632940da4b41bfcf34e7658c5b94ae2
dc.subjectarticleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectadulten
dc.subjectmajor clinical studyen
dc.subjectpriority journalen
dc.subjectTreatment Outcomeen
dc.subjectadolescenten
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectChilden
dc.subjectHIV Infectionsen
dc.subjecthighly active antiretroviral therapyen
dc.subjectvirus loaden
dc.subjectvirus RNAen
dc.subjectpolymerase chain reactionen
dc.subjectAcquired Immunodeficiency Syndromeen
dc.subjectViral Loaden
dc.subjectCohort Studiesen
dc.subjectHuman immunodeficiency virus 1en
dc.subjectHIV-1en
dc.subjectcryopreservationen
dc.subjectsaquinaviren
dc.subjectproteinase inhibitoren
dc.subjecthemophiliaen
dc.subjectvirus DNAen
dc.subjectlymphocyteen
dc.subjectDNA, Viralen
dc.subjectRNA directed DNA polymerase inhibitoren
dc.subjectAntiretroviral Therapy, Highly Activeen
dc.subjectChild, Preschoolen
dc.subjectRNA, Viralen
dc.subjectDNA determinationen
dc.subjectLeukocytes, Mononuclearen
dc.subjectHemophilia Aen
dc.subjectAntiretroviral therapyen
dc.subjectCellular HIV-1 DNA loaden
dc.subjectHIV-1 RNA rebounden
dc.titleCellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1097/00002030-200411190-00006
dc.description.volume18
dc.description.startingpage2261
dc.description.endingpage2267
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :35</p>en
dc.source.abbreviationAIDSen
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]
dc.gnosis.orcid0000-0002-5340-7109


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