dc.contributor.author | Hessler, P. E. | en |
dc.contributor.author | Larsen, P. E. | en |
dc.contributor.author | Constantinou, Andreas I. | en |
dc.contributor.author | Schram, K. H. | en |
dc.contributor.author | Weber, J. M. | en |
dc.creator | Hessler, P. E. | en |
dc.creator | Larsen, P. E. | en |
dc.creator | Constantinou, Andreas I. | en |
dc.creator | Schram, K. H. | en |
dc.creator | Weber, J. M. | en |
dc.date.accessioned | 2019-11-04T12:50:42Z | |
dc.date.available | 2019-11-04T12:50:42Z | |
dc.date.issued | 1997 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53128 | |
dc.description.abstract | A search for an abundant and economical source of isoflavones, particularly genistein, led to the discovery that the erythromycin-producing organism Saccharopolyspora erythraea also produces this promising new cancer-prevention agent. Erythromycin fermentation is a large-scale, soybean-based process used world-wide for the commercial production of this medically important antibiotic. Results from this study indicate that genistein (the glucoside form of genistein), which is added to the fermentation in the soybean media, was converted to genistein through the action of a β-glucosidase produced bv the organism. Genistein was co-extracted with erythromycin from the fermentation broth, then separated from erythromycin during the second step of the purification process for the production of erythromycin. | en |
dc.source | Applied Microbiology and Biotechnology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030927901&doi=10.1007%2fs002530050947&partnerID=40&md5=13e6066cb49cc4701cd96553df4637a7 | |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | nonhuman | en |
dc.subject | biosynthesis | en |
dc.subject | isolation and purification | en |
dc.subject | Molecular Structure | en |
dc.subject | Bacteria (microorganisms) | en |
dc.subject | DNA Topoisomerases, Type II | en |
dc.subject | genistein | en |
dc.subject | isoflavone | en |
dc.subject | soybean | en |
dc.subject | Chromatography, High Pressure Liquid | en |
dc.subject | Isoflavones | en |
dc.subject | Glycine max | en |
dc.subject | Soybeans | en |
dc.subject | Electrophoresis, Agar Gel | en |
dc.subject | beta-Glucosidase | en |
dc.subject | Chromatography, Thin Layer | en |
dc.subject | Culture Media | en |
dc.subject | drug purification | en |
dc.subject | erythromycin | en |
dc.subject | fermentation | en |
dc.subject | Mass Spectrometry | en |
dc.subject | saccharopolyspora | en |
dc.subject | Saccharopolyspora erythraea | en |
dc.title | Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s002530050947 | |
dc.description.volume | 47 | |
dc.description.startingpage | 398 | |
dc.description.endingpage | 404 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :35</p> | en |
dc.source.abbreviation | Appl.Microbiol.Biotechnol. | en |
dc.contributor.orcid | Constantinou, Andreas I. [0000-0003-0365-1821] | |
dc.gnosis.orcid | 0000-0003-0365-1821 | |