The HPV16 oncogenes cause aberrant stem cell mobilization
dc.contributor.author | Michael, S. | en |
dc.contributor.author | Lambert, P. F. | en |
dc.contributor.author | Strati, Katerina | en |
dc.creator | Michael, S. | en |
dc.creator | Lambert, P. F. | en |
dc.creator | Strati, Katerina | en |
dc.date.accessioned | 2019-11-04T12:52:21Z | |
dc.date.available | 2019-11-04T12:52:21Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53250 | |
dc.description.abstract | Human Papilloma Virus related epithelial cancers have been speculated to derive from virus-infected tissue stem cells. Stem cells also are thought to provide a reservoir of latently infected cells that can persist for long periods. In this study we have examined the effects of HPV16 E6 and E7 oncogenes on multipotent epithelial stem cells, using in vivo systems. Our results show that expression of HPV16 oncogenes reduces the number of bulge label-retaining cells within hair follicles at telogen suggesting aberrant mobilization, a result supported by increased mobilization upon acute anagen induction. Importantly the loss of relative quiescence, a hallmark feature of stem cells, occurs in the absence of a reduction in other stem cell markers. This points to an atypical stem cell compartment in the context of E6 and E7 expression. We hypothesize that this aberrant compartment may have important roles in the viral life cycle and/or ensuing carcinogenesis. © 2013 Elsevier Inc. | en |
dc.source | Virology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880508411&doi=10.1016%2fj.virol.2013.04.008&partnerID=40&md5=f0ab9bdd054ab10d53ccbab72db28e2a | |
dc.subject | article | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | cell proliferation | en |
dc.subject | oncogene | en |
dc.subject | nonhuman | en |
dc.subject | gene expression | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal cell | en |
dc.subject | animal experiment | en |
dc.subject | animal tissue | en |
dc.subject | mouse | en |
dc.subject | squamous epithelium | en |
dc.subject | Epithelial Cells | en |
dc.subject | cell marker | en |
dc.subject | Stem cells | en |
dc.subject | in vivo study | en |
dc.subject | virus genome | en |
dc.subject | Repressor Proteins | en |
dc.subject | HPV | en |
dc.subject | Human papillomavirus type 16 | en |
dc.subject | Human papillomavirus | en |
dc.subject | Human papillomavirus 16 | en |
dc.subject | Oncogene Proteins, Viral | en |
dc.subject | Papillomavirus E7 Proteins | en |
dc.subject | protein E6 | en |
dc.subject | protein E7 | en |
dc.subject | cell compartmentalization | en |
dc.subject | Cell Transformation, Viral | en |
dc.subject | E6 | en |
dc.subject | E6 gene | en |
dc.subject | E7 | en |
dc.subject | E7 gene | en |
dc.subject | hair follicle | en |
dc.subject | hair growth | en |
dc.subject | Hematopoietic Stem Cell Mobilization | en |
dc.subject | multipotent stem cell | en |
dc.subject | stem cell mobilization | en |
dc.subject | transcription factor NFAT | en |
dc.title | The HPV16 oncogenes cause aberrant stem cell mobilization | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.virol.2013.04.008 | |
dc.description.volume | 443 | |
dc.description.startingpage | 218 | |
dc.description.endingpage | 225 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :12</p> | en |
dc.source.abbreviation | Virology | en |
dc.contributor.orcid | Strati, Katerina [0000-0002-2332-787X] | |
dc.gnosis.orcid | 0000-0002-2332-787X |
Files in this item
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |