dc.contributor.author | Nagel, A. C. | en |
dc.contributor.author | Apidianakis, Yiorgos | en |
dc.contributor.author | Wech, I. | en |
dc.contributor.author | Maier, D. | en |
dc.contributor.author | Delidakis, Christos | en |
dc.contributor.author | Preiss, A. | en |
dc.creator | Nagel, A. C. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.creator | Wech, I. | en |
dc.creator | Maier, D. | en |
dc.creator | Delidakis, Christos | en |
dc.creator | Preiss, A. | en |
dc.date.accessioned | 2019-11-04T12:52:23Z | |
dc.date.available | 2019-11-04T12:52:23Z | |
dc.date.issued | 2000 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53266 | |
dc.description.abstract | The E(spl) complex (E(spl)-C) contains three different classes of genes that are downstream of Notch signaling. The bHLH genes mediate the Notch signal by repressing proneural gene activity, for example during the singularization of mechanosensory organ precursor cells (SOPs). Genes of the second class, the E(spl) m4/mα family, antagonize this process if overexpressed. Here we show that this is based on dominant-negative effects since RNA interference gives neurogenic phenotypes indistinguishable from E(spl)-C mutations. Furthermore, a third member of the m4/mα gene family, named bbu/tom, behaves differently with respect to RNA expression patterns, its regulation by Notch signaling and loss of function phenotypes. Copyright (C) 2000 Elsevier Science Ireland Ltd. | en |
dc.source | Mechanisms of development | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034333470&doi=10.1016%2fS0925-4773%2800%2900446-9&partnerID=40&md5=38086328873b62ed5eb43e0e96cd5736 | |
dc.subject | mα | el |
dc.subject | article | en |
dc.subject | priority journal | en |
dc.subject | Hyperplasia | en |
dc.subject | nonhuman | en |
dc.subject | phenotype | en |
dc.subject | Animal | en |
dc.subject | animal cell | en |
dc.subject | animal experiment | en |
dc.subject | RNA | en |
dc.subject | Signal Transduction | en |
dc.subject | transcription regulation | en |
dc.subject | Base Sequence | en |
dc.subject | gene mutation | en |
dc.subject | DNA Primers | en |
dc.subject | gene overexpression | en |
dc.subject | Mutation | en |
dc.subject | gene deletion | en |
dc.subject | gene function | en |
dc.subject | Membrane Proteins | en |
dc.subject | Notch | en |
dc.subject | gene activity | en |
dc.subject | Support, Non-U.S. Gov't | en |
dc.subject | Drosophila | en |
dc.subject | Insect Proteins | en |
dc.subject | fly | en |
dc.subject | sense organ | en |
dc.subject | ectoderm | en |
dc.subject | nervous system development | en |
dc.subject | Neurogenesis | en |
dc.subject | multigene family | en |
dc.subject | double stranded RNA | en |
dc.subject | RNA interference | en |
dc.subject | E(spl) | en |
dc.subject | Barbu | en |
dc.subject | bbu | en |
dc.subject | Bearded | en |
dc.subject | Brd | en |
dc.subject | Brd-C | en |
dc.subject | Bristle | en |
dc.subject | Dominant-negative | en |
dc.subject | Double-strand RNA | en |
dc.subject | E(spl)-C | en |
dc.subject | Enhancer of split | en |
dc.subject | Gain of function | en |
dc.subject | Gene family | en |
dc.subject | Genes, Insect | en |
dc.subject | Lateral specification | en |
dc.subject | Loss of function | en |
dc.subject | m4 | en |
dc.subject | Mechanosensory organ | en |
dc.subject | Nervous System | en |
dc.subject | precursor cell | en |
dc.subject | protein Notch | en |
dc.subject | RNAi | en |
dc.subject | Sensory organ precursor | en |
dc.subject | tom | en |
dc.subject | twin of m4 | en |
dc.title | Neural hyperplasia induced by RNA interference with m4/mα gene activity | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/S0925-4773(00)00446-9 | |
dc.description.volume | 98 | |
dc.description.startingpage | 19 | |
dc.description.endingpage | 28 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :7</p> | en |
dc.source.abbreviation | Mech.Dev. | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 | |