Developmental biology: Our fly cousins' gut
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What do we humans have in common with flies? Quite a lot, at least at the cellular and molecular levels. Our intestine, for instance, is similar to that of the fly, not only in function but also in its development and maintenance. © 2008 Macmillan Publishers Limited. All rights reserved.
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Apidianakis, Yiorgos; Rahme, L. G. (2011)Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...
Kux, K.; Pitsouli, Chrysoula (2014)The intestine, as a barrier epithelium, serves in the first line of defense against invading pathogens and damaging agents that enter the body via food ingestion. Maintenance of intestinal homeostasis is therefore key to ...
Apidianakis, Yiorgos; Pitsouli, Chrysoula; Perrimon, N.; Rahme, L. (2009)Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasingly ...