Human papillomavirus association with head and neck cancers: Understanding virus biology and using it in the development of cancer diagnostics
Date
2008ISSN
1753-0059Source
Expert Opinion on Medical DiagnosticsVolume
2Pages
11-20Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
The link between human papillomaviruses (HPVs) and human cervical cancers has long been established. However, HPVs are now being detected in another type of cancer not previously associated with this virus, head and neck squamous cell carcinoma (HNSCC). This review will focus on experimental data supporting the view that HPVs contribute to the etiology of a subset of HNSCC. The authors further put forth the argument that HPV-associated HNSCC deserves to be recognized as a distinct disease in the clinic and, as such, needs to be appropriately diagnosed. An overview of studies that have helped dissect the role of HPVs in HNSCC and that may be helpful in the development of new diagnostic tools for discriminating this type of HNSCC is provided. © 2008 Informa UK Ltd.
Collections
Cite as
Related items
Showing items related by title, author, creator and subject.
-
Article
Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses
Iacovides, D.; Michael, S.; Achilleos, Charis; Strati, Katerina (2013)A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...
-
Article
Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model
Strati, Katerina; Pitot, H. C.; Lambert, P. F. (2006)Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer mortality worldwide. Recent reports have associated a subset of HNSCC with high-risk human papillomaviruses (HPVs), particularly HPV16, the same ...
-
Article
The role of human papilloma virus and p16 in occult primary of the head and neck: A comprehensive review of the literature
Fotopoulos, George; Pavlidis, Nicholas (2015)Cancer of unknown primary of the head and neck is a challenging entity for the oncologist. The role of human papilloma virus/p16 in carcinogenesis and in prognosis is well established in certain HNSCC especially in that ...