Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro
Date
1998Author
Zhang, Y. -JDragic, T.
Cao, Yun Zhen
Kostrikis, Leontios G.
Kwon, D. S.
Littman, D. R.
Kewalramani, V. N.
Moore, J. P.
ISSN
0022-538XSource
Journal of virologyVolume
72Pages
9337-9344Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
We have tested a panel of pediatric and adult human immunodeficiency virus type 1 (HIV-1) primary isolates for the ability to employ the following proteins as coreceptors during viral entry: CCR1, CCR2b, CCR3, CCR4, CCR5, CCR8, CXCR4, Bonzo, BOB, GPR1, V28, US28, and APJ. Most non-syncytium- inducing isolates could utilize only CCR5. All syncytium-inducing viruses used CXCR4, some also employed V28, and one (DH123) used CCR8 and APJ as well. A longitudinal series of HIV-1 subtype B isolates from an infected infant and its mother utilized Bonzo efficiently, as well as CCR5. The maternal isolates, which were syncytium inducing, also used CXCR4, CCRS, V28, and APJ.
Collections
Cite as
Related items
Showing items related by title, author, creator and subject.
-
Article
Viral correlates of HIV-1 disease
Anastassopoulou, C. G.; Kostrikis, Leontios G. (2005)The transmission of HIV and the progression of HIV disease are influenced not only by a large number of human host factors, but also by certain correlates of the ever fluctuating virus quasispecies. The present review ...
-
Article
Shared mechanisms in stemness and carcinogenesis: Lessons from oncogenic viruses
Iacovides, D.; Michael, S.; Achilleos, Charis; Strati, Katerina (2013)A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared ...
-
Article
Re-analysis of human immunodeficiency virus type 1 isolates from Cyprus and Greece, initially designated 'subtype I', reveals a unique complex A/G/H/K/? mosaic pattern
Paraskevis, Dimitrios N.; Magiorkinis, M.; Vandamme, A. M.; Kostrikis, Leontios G.; Hatzakis, Angelos E. (2001)Human immunodeficiency virus type 1 (HIV-1) has been classified into three main groups and 11 distinct subtypes. Moreover, several circulating recombinant forms (CRFs) of HIV-1 have been recently documented to have spread ...