Structural motifs and biological studies of new antimony(iii) iodide complexes with thiones
dc.contributor.author | Ozturk, I. | en |
dc.contributor.author | Filimonova, S. | en |
dc.contributor.author | Hadjikakou, Sotiris K. | en |
dc.contributor.author | Kourkoumelis, Nikolaos | en |
dc.contributor.author | Dokorou, Vaso N. | en |
dc.contributor.author | Manos, Manolis J. | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Barsan, M. M. | en |
dc.contributor.author | Butler, I. S. | en |
dc.contributor.author | Milaeva, E. R. | en |
dc.contributor.author | Balzarini, J. | en |
dc.contributor.author | Hadjiliadis, Nick | en |
dc.creator | Ozturk, I. | en |
dc.creator | Filimonova, S. | en |
dc.creator | Hadjikakou, Sotiris K. | en |
dc.creator | Kourkoumelis, Nikolaos | en |
dc.creator | Dokorou, Vaso N. | en |
dc.creator | Manos, Manolis J. | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Barsan, M. M. | en |
dc.creator | Butler, I. S. | en |
dc.creator | Milaeva, E. R. | en |
dc.creator | Balzarini, J. | en |
dc.creator | Hadjiliadis, Nick | en |
dc.date.accessioned | 2019-11-21T06:21:50Z | |
dc.date.available | 2019-11-21T06:21:50Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55927 | |
dc.description.abstract | Eight new antimony(III) iodide complexes of the heterocyclic thioamides, 2-mercapto-1-methylimidazole (MMI), 2-mercaptobenzlmidazole (MBZIM), 5-ethoxy-2-mercaptobenzimldazole (EtMBZIM), 2-mercaptothiazolidine (MTZD), 3-methyl-2-mercaptobenzothiazole (NMeMBZT), 2-mercapto-3,4,5,6- tetrahydropyrlmidine (tHPMT), 2-mercaptopyrldlne (PYT), and 2-mercaptopyrimldlne (PMT) of formulas {[Sbl3(MMl)2] -MeOH} (1), [Sbl 3(MBZIM)2] (2), {[Sbl2(μ2-I) (EtMBZIM)2]2-H2O} (3), [Sbl3(MTZD)] (4), [(NMeMBZT)Sbl2(μ2-I)2(μ2- S-NMeMBZT)Sbl2 (NMeMBZT)] (5), {[Sbl3OHPMT) 3]-MeOH} (6), [Sbl3(PYT)] (7) and [Sbl3(PMT) 2] (8), have been synthesized and characterized by elemental analysis, FT-IR spectroscopy, FT-Raman spectroscopy and TG-DTA analysis. The crystal structures of 3,4,5,6, and 7 were also determined by X-ray diffraction. The complexes show interesting structural motifs. Complex 6 is a monomer, with octahedral (Oh) geometry around the metal ion formed by three sulfur and three iodide atoms. Complexes 3 and 5 are dimers, with a square pyramidal (SP) geometry in each monomeric unit, while complexes 4 and 7 are polymers with pseudotrlgonal bipyramidal (ψ-TBP). Two or three sulfur atoms from thioamide ligands and three iodide atoms are bound to Sb atoms forming building blocks for the dimers and polymers. Strong intramolecular interactions between μ2-I and/or μ2-S and Sb atoms stabilize both structures. In dimer complex 5, two terminal iodide and one terminal sulfur atom are bonded to the Sb ion, while two μ2-I and one μ2-S bridging atoms bridge the metal Ions forming ψ-Oh geometry. Computational studies using multivariant linear regression (MLR) and artificial neural networks (ANN) and considering biological results (50% inhibitory concentration, IC50) as dependent variables derived a theoretical equation for IC50 values of the complexes studied. The calculated IC50 values are compared satisfactorily with the experimental inhibitory activity of the complexes measured. Complexes 3 - 7 were used to study their influence upon the catalytic peroxidation of linoleic acid by the enzyme Lipoxygenase (LOX). Compounds 1 - 8 were also tested for In vitro cytotoxicity, and they showed mostly a moderate cytostatic activity against a variety of tumor cell lines but comparable with those found for the antimony(III) chloride and bromide complexes, reported earlier [Ozturk et al. Inorg. Chem. 2007, 46, 2861-2866 | en |
dc.description.abstract | Ozturk et al. Inorg. Chem. 2009, 48, 2233-2245]. © 2009 American Chemical Society. | en |
dc.source | Inorganic chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-74549119472&doi=10.1021%2fic901442e&partnerID=40&md5=6b6e2100baba2352f44ac4ff2f128c84 | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Neoplasms | en |
dc.subject | Humans | en |
dc.subject | drug effect | en |
dc.subject | neoplasm | en |
dc.subject | metabolism | en |
dc.subject | Animals | en |
dc.subject | animal | en |
dc.subject | cell survival | en |
dc.subject | chemistry | en |
dc.subject | cytostatic agent | en |
dc.subject | chemical structure | en |
dc.subject | X ray crystallography | en |
dc.subject | antimony | en |
dc.subject | tumor cell line | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Models, Molecular | en |
dc.subject | Crystallography, X-Ray | en |
dc.subject | iodide | en |
dc.subject | Iodides | en |
dc.subject | lipoxygenase | en |
dc.subject | Cytostatic Agents | en |
dc.subject | thioketone | en |
dc.subject | Thiones | en |
dc.title | Structural motifs and biological studies of new antimony(iii) iodide complexes with thiones | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1021/ic901442e | |
dc.description.volume | 49 | |
dc.description.issue | 2 | |
dc.description.startingpage | 488 | |
dc.description.endingpage | 501 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :36</p> | en |
dc.source.abbreviation | Inorg.Chem. | en |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Hadjikakou, Sotiris K. [0000-0001-9556-6266] | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0001-9556-6266 |
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