Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Submit Date

Αποτελέσματα 1-20 από 28

    • Master Thesis  Open Access

      Hypomethylation of Alu Elements in chronic lymphocytic leukemia 

      Prodromou, Marios (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)
      CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...
    • Master Thesis  Open Access

      Detection of SARS-CoV-2 in Clinical Samples Using Mismatch-Tolerant Molecular Beacons and Real-Time RT-PCR 

      Stathi, Georgia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-14)
      Infectious diseases that arise from pathogens are considered as a major threat towards global public health. Most recently, the novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome ...
    • Master Thesis  Open Access

      The amyloid hypothesis of Alzheimer’s Disease and its current treatment 

      Komodromou, Artemis A. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-14)
      Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the commonest cause of dementia in the elderly population worldwide. It is a multifactorial disorder, characterized by extracellular β-amyloid peptide ...
    • Master Thesis  Open Access

      Molecular mechanisms that Hepatitis B virus uses to induce Hepatocellular Carcinoma 

      Frangou, Antrea (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-07)
      Hepatitis B is an infectious liver disease caused by the Hepatitis B virus (HBV). HBV is a small DNA virus that mainly affects hepatocytes, which are the main liver cells, and it has the ability to replicate by reverse ...
    • Master Thesis  Open Access

      Inhibition of Focal Adhesion Kinase as an anti-metastatic therapy 

      Dionysi, Eleni N. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-07)
      Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, has a physiological role in cell migration, cell survival, wound healing, and cell cycle progression, via both kinase-dependent and kinase-independent functions. ...
    • Master Thesis  Open Access

      Modelling Glioblastoma Angiogenesis in Drosophila larvae 

      Konstantinou, Anna G. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
      Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
    • Master Thesis  

      Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response 

      Papa, Christina C. (2023-05-28)
      N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...
    • Master Thesis  Open Access

      Investigation of the role of cytoskeleton protein KATNAL2 in ribosomal gene transcription in mouse cells 

      Timotheou, Kyriaki M (2023-05-23)
      The discovery that katanin-like cytoskeleton protein KATNAL2, in addition to its intracellular localization at MTs and sites associated with MTs (centrioles, cilia), also, unexpectedly, resides in the nucleolus, suggests ...
    • Master Thesis  Open Access

      Adherens Junctions spatially guide ECM deposition by stimulating integrin activation and clustering 

      Zheltkova, Maria (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)
      The extracellular matrix (ECM) plays an essential role in all multicellular organisms as a substrate for cell anchorage and tissue scaffolding. It is involved in diverse processes such as cell proliferation and survival, ...
    • Master Thesis  Open Access

      Quantifying the fragmentation levels of amphibian, reptile, and terrestrial mammal habitats inside and outside of Natura 2000 sites within the European Union 

      Economides, Sophia (2023-05-25)
      Natural landscapes are constantly being modified and fragmented through a plethora of human activities, such as urbanisation and agriculture. Landscape fragmentation can have multiple negative effects on biodiversity. For ...
    • Master Thesis  Open Access

      Application of conservation genetics in conservation planning, with a special focus on the impacts of hybridization on birds and their conservation 

      Hajjar, Vanessa (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-06-01)
      Biodiversity consists of all different live forms found in Earth. It is important to sustain it as it has several important aspects, such as maintaining ecosystems, helping with their proper functioning and it also plays ...
    • Master Thesis  Open Access

      Human immune responses upon SARS-CoV-2 infection- inflammation and cytokine storm 

      Syrimi, Andriani (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)
      Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in December 2019 in the city of Wuhan, China, causing the COVID-19 pandemic of acute respiratory ...
    • Master Thesis  Open Access

      Investigating the role of Methyl CpG Binding proteins in Cervical Cancer 

      Patera, Eleftherios (2023-05-12)
      DNA methylation (5mC) is one of the main epigenetic modifications that drive gene regulation. Methyl CpG binding proteins (MBDs) bind methylated DNA and recruit the nucleosome remodelling and deacetylase complex (Nurd) ...
    • Master Thesis  

      Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40 

      Kouma, Maria P. (2023-05-24)
      NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...
    • Master Thesis  Open Access

      The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers 

      Andreou, Vasiliki (2023-05-18)
      Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...
    • Master Thesis  

      Development of a de novo Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection and Discrimination of SARS-CoV-2 Variants of Concern 

      Aristokleous, Antonia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-16)
      The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and is the causative agent of the Coronavirus Disease 2019 (COVID-19). Since its emergence it has led to a global pandemic with devastating ...
    • Master Thesis  Open Access

      Novel molecular approaches to treat colorectal cancer 

      Argyrou, Christina (2021-12-10)
      Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...
    • Master Thesis  Open Access

      The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation 

      Alshikh Saleh, Ahmad (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)
      Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...
    • Master Thesis  Open Access

      Recombinant Poliovirus a therapeutic agent for Cancer 

      Mbonu, Helen (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05)
      Cancer is a leading cause of global mortality, and its burden is growing despite the availability of standard treatment methods. Genetically and Morphologically tumor cells differ from normal cells. However, cancers arise ...
    • Master Thesis  Open Access

      Spatiotemporal vocal interactions in a ground-dwelling Neotropical passerine 

      Elia, Stavroula (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-11)
      In many species, communication involves an exchange of information between the sender and the receiver, by using different types of signals. Among the different types of communication, acoustic communication has been studied ...