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dc.contributor.authorSoignier, R. D.en
dc.contributor.authorVaccarino, A. L.en
dc.contributor.authorFanti, Kostas A.en
dc.contributor.authorWilson, A. M.en
dc.contributor.authorZadina, J. E.en
dc.creatorSoignier, R. D.en
dc.creatorVaccarino, A. L.en
dc.creatorFanti, Kostas A.en
dc.creatorWilson, A. M.en
dc.creatorZadina, J. E.en
dc.date.accessioned2017-07-27T10:22:16Z
dc.date.available2017-07-27T10:22:16Z
dc.date.issued2004
dc.identifier.issn03043940 (ISSN)
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/37629
dc.description.abstractThe present study examined the development of analgesic tolerance to endomorphin-1 (EM1), endomorphin-2 (EM2), and morphine, and cross-tolerance among these drugs. Male Swiss Webster mice were injected i.c.v. with EM1, EM2, morphine, or vehicle once daily for 5 days, and tested for analgesia in the tail flick test. To determine the extent of cross-tolerance, on the sixth day mice from each of the above groups received i.c.v. injections of EM1, EM2, morphine, or vehicle before analgesic testing. The development of tolerance to EM1 and EM2 closely resembled that of morphine. Complete, symmetrical cross-tolerance was observed between all drugs in the study. These results demonstrate a time-course and extent of tolerance similar to morphine, and support a common mechanism of action through the mu-opioid receptor. © 2004 Published by Elsevier Ireland Ltd.en
dc.sourceNeuroscience lettersen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-3242798948&doi=10.1016%2fj.neulet.2004.05.046&partnerID=40&md5=6641b8a17d3e530d7613cf883776efd8
dc.subjectAnalgesiaen
dc.subjectAntinociceptionen
dc.subjectHot-plateen
dc.subjectOpioiden
dc.subjectPainen
dc.subjectPeptidesen
dc.subjectAnalgesic agenten
dc.subjectDrug vehicleen
dc.subjectEndomorphin 1en
dc.subjectEndomorphin 2en
dc.subjectMorphineen
dc.subjectMu opiate receptoren
dc.subjectAnesthesia mechanismen
dc.subjectAnimal experimenten
dc.subjectArticleen
dc.subjectControlled studyen
dc.subjectDrug cross toleranceen
dc.subjectDrug screeningen
dc.subjectDrug toleranceen
dc.subjectMaleen
dc.subjectMouseen
dc.subjectNonhumanen
dc.subjectObservationen
dc.subjectPriority journalen
dc.subjectTimeen
dc.subjectAnalgesics, opioiden
dc.subjectAnimalsen
dc.subjectInjections, intraventricularen
dc.subjectMiceen
dc.subjectOligopeptidesen
dc.subjectReceptors, opioid, muen
dc.titleAnalgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice; 15276249en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.neulet.2004.05.046
dc.description.volume366
dc.description.issue2
dc.description.startingpage211
dc.description.endingpage214
dc.author.facultyΣχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and Education
dc.author.departmentΤμήμα Ψυχολογίας / Department of Psychology
dc.type.uhtypeArticleen
dc.description.notesJ2: Neurosci. Lett.; Cited By :9; Export Date: 12 July 2017; CODEN: NELED; Correspondence Address: Soignier, R.D.; Louisiana State University, School of Medicine, 533 Bolivar St., Room 324, 70112, New Orleans, LA, United States; email: rsoign@lsuhsc.eduen
dc.source.abbreviationNeurosci.Lett.en
dc.contributor.orcidFanti, Kostas A. [0000-0002-3484-7483]


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