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dc.contributor.authorAngeli, S.en
dc.contributor.authorStylianopoulos, T.en
dc.creatorAngeli, S.en
dc.creatorStylianopoulos, T.en
dc.date.accessioned2019-05-06T12:23:20Z
dc.date.available2019-05-06T12:23:20Z
dc.date.issued2016
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48214
dc.description.abstractBiomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical models ignore direct mechanical interactions of the tumor with the normal brain. Here, we developed a clinically relevant model, which predicts tumor growth accounting directly for mechanical interactions. A three-dimensional model of the gray and white matter and the cerebrospinal fluid was constructed from magnetic resonance images of a normal brain. Subsequently, a biphasic tissue growth theory for an initial tumor seed was employed, incorporating the effects of radiotherapy. Additionally, three different sets of brain tissue properties taken from the literature were used to investigate their effect on tumor growth. Results show the evolution of solid stress and interstitial fluid pressure within the tumor and the normal brain. Heterogeneous distribution of the solid stress exerted on the tumor resulted in a 35% spatial variation in cancer cell proliferation. Interestingly, the model predicted that distant from the tumor, normal tissues still undergo significant deformations while it was found that intratumoral fluid pressure is elevated. Our predictions relate to clinical symptoms of brain cancers and present useful tools for therapy planning. © 2016 Elsevier Ltd.en
dc.language.isoengen
dc.sourceJournal of Biomechanicsen
dc.subjectMathematical modelsen
dc.subjectModelsen
dc.subjecthumanen
dc.subjectBrain Neoplasmsen
dc.subjectHumansen
dc.subjectcontrolled studyen
dc.subjectpredictionen
dc.subjectpriority journalen
dc.subjecthuman tissueen
dc.subjecttreatment outcomeen
dc.subjectcancer radiotherapyen
dc.subjectbrain tumoren
dc.subjectbiological modelen
dc.subjectRadiotherapyen
dc.subjecttherapy effecten
dc.subjectpathologyen
dc.subjecttumor growthen
dc.subjectnuclear magnetic resonance imagingen
dc.subjecttreatment responseen
dc.subjectArticleen
dc.subjectBiologicalen
dc.subjectcancer cellen
dc.subjecthuman cellen
dc.subjectcell survivalen
dc.subjectMagnetic resonance imagingen
dc.subjectwhite matteren
dc.subjectthree dimensional imagingen
dc.subjectMagnetic resonanceen
dc.subjectCell proliferationen
dc.subjectPoro-elasticityen
dc.subjectTumorsen
dc.subjectBrainen
dc.subjectInterstitial fluid pressureen
dc.subjectInterstitial fluid pressuresen
dc.subjectSolid stressen
dc.subjectTissueen
dc.subjectBiomechanical Phenomenaen
dc.subjectBiomechanicsen
dc.subjectCerebrospinal fluiden
dc.subjectDiseasesen
dc.subjectextracellular fluiden
dc.subjectgray matteren
dc.subjectHeterogeneous distributionsen
dc.subjectHistologyen
dc.subjecthuman experimenten
dc.subjectImage reconstructionen
dc.subjectintratumoral fluid pressureen
dc.subjectmathematical analysisen
dc.subjectMathematical modelingen
dc.subjectMechanical interactionsen
dc.subjectMechanical Phenomenaen
dc.subjectmechanicsen
dc.subjectnormal humanen
dc.subjectnuclear magnetic resonance scanneren
dc.subjectpressureen
dc.subjectradiation responseen
dc.subjectRadiation treatmentsen
dc.subjectspatial analysisen
dc.subjectThree-dimensional modelen
dc.subjecttissue growthen
dc.subjecttissue pressureen
dc.subjectTumor progressionsen
dc.titleBiphasic modeling of brain tumor biomechanics and response to radiation treatmenten
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.jbiomech.2016.03.029
dc.description.volume49
dc.description.startingpage1524
dc.description.endingpage1531
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages1524-1531


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