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Remodeling components of the tumor microenvironment to enhance cancer therapy

dc.contributor.authorGkretsi, V.en
dc.contributor.authorStylianou, A.en
dc.contributor.authorPapageorgis, P.en
dc.contributor.authorPolydorou, C.en
dc.contributor.authorStylianopoulos, T.en
dc.creatorGkretsi, V.en
dc.creatorStylianou, A.en
dc.creatorPapageorgis, P.en
dc.creatorPolydorou, C.en
dc.creatorStylianopoulos, T.en
dc.date.accessioned2019-05-06T12:23:38Z
dc.date.available2019-05-06T12:23:38Z
dc.date.issued2015
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48371
dc.description.abstractSolid tumor pathophysiology is characterized by an abnormal microenvironment that guides tumor progression and poses barriers to the efficacy of cancer therapies. Most common among tumor types are abnormalities in the structure of the tumor vasculature and stroma. Remodeling the tumor microenvironment with the aim to normalize any aberrant properties has the potential to improve therapy. In this review, we discuss structural abnormalities of the tumor microenvironment and summarize the therapeutic strategies that have been developed to normalize tumors as well as their potential to enhance therapy. Finally, we present different in vitro models that have been developed to analyze and better understand the effects of the tumor microenvironment on cancer cell behavior. � 2015 Gkretsi, Stylianou, Papageorgis, Polydorou and Stylianopoulos.en
dc.language.isoengen
dc.sourceFrontiers in Oncologyen
dc.subjectReviewen
dc.subjecthumanen
dc.subjecttumor microenvironmenten
dc.subjectcell proliferationen
dc.subjectcolon canceren
dc.subjectliver cell carcinomaen
dc.subjectnonhumanen
dc.subjecttransforming growth factor betaen
dc.subjecttumor growthen
dc.subjecttumor vascularizationen
dc.subjectvasculotropinen
dc.subjectcancer therapyen
dc.subjectpancreas canceren
dc.subjectapoptosisen
dc.subjectcell invasionen
dc.subjectcell migrationen
dc.subjectchromosome aberrationen
dc.subjectbreast tumoren
dc.subjectglioblastomaen
dc.subjectatomic force microscopyen
dc.subjectextracellular matrixen
dc.subjecttumor spheroiden
dc.subjectblood vessel permeabilityen
dc.subjectcell motilityen
dc.subjectIn vitro modelsen
dc.subjectmechanical stressen
dc.subjectStress alleviationen
dc.subjectstroma cellen
dc.subjectTumor vessel permeabilityen
dc.subjectVascular normalizationen
dc.subjectVessel compressionen
dc.titleRemodeling components of the tumor microenvironment to enhance cancer therapyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3389/fonc.2015.00214
dc.description.volume5
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.gnosis.orcid0000-0002-3093-1696


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